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YDL164C / CDC9



Section 1: Phenotypes.
Gene-drug relationships for YDL164C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL164C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CDC9 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 14.925 4.1185e-11
miconazole 0.2 uM 13.0982 2.8642e-10
nocodazole 2 ug/ml 10.8588 < 1e-12
drofenine hydrochloride 750 uM 9.04833 5.2692e-12
methotrexate 500 uM 8.41299 6.491e-10
thiabendazole 250 uM 5.91664 1.7991e-07
thiabendazole 500 uM 5.69376 3.9009e-07
alverine citrate 500 uM 5.64487 5.4077e-05
5-fluorocytosine 15.6 uM 5.13712 2.6417e-06
tunicamycin 0.15 uM 5.115 5.1928e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YDL164C

Top 10 functional gene interactors with YDL164C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CDC9 by heterozygous co-sensitivity:

Query Interactor Correlation
CDC9 RIB4 0.58424
CDC9 YMR293C 0.58379
CDC9 YLR458W 0.5734
CDC9 MTG1 0.56786
CDC9 YML094C-A 0.55547
CDC9 YBR124W 0.55482
CDC9 CAF17 0.55085
CDC9 RNA1 0.5478
CDC9 YGR272C 0.54665
CDC9 PRP24 0.54611

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDL164C

Other databases:

Visit YDL164C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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