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Yeast Fitness
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YDL138W / RGT2



Section 1: Phenotypes.
Gene-drug relationships for YDL138W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL138W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RGT2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
paraquat 2000 uM 6.15521 3.4655e-07
methotrexate 500 uM 5.56379 1.9255e-06
ketoconazole 11.8 uM 5.48958 2.4726e-05
caspofungin 10 nM 4.84671 7.049e-06
methotrexate 125 uM 4.8421 1.5715e-05
lovastatin 77.2 uM 3.81183 0.00020026
fluconazole 65.3 uM 3.42515 0.00064236
methotrexate 250 uM 3.39881 0.00091433
mechlorethamine 500 uM 3.37012 0.00075468
bufexamac 1000 uM 3.20115 0.0012277

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RGT2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 8.29453 5.5554e-10
synthetic complete for BY4743 0 6.75469 0.0033142
synthetic complete for BY4743 0 4.48735 0.00058284
paraquat 5000 uM 3.57525 0.00053659
nocodazole 10 ug/ml 3.54975 0.0011446
yp glycerol 0 3.02232 0.0038401
sodium fluoride 20000 uM 2.92545 0.0030439
methotrexate 500 uM 2.86385 0.0051598
synthetic complete for BY4743 400 uM 2.78616 0.0063345
synthetic complete for BY4743 0 2.75464 0.010158

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL138W

Top 10 functional gene interactors with YDL138W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RGT2 by heterozygous co-sensitivity:

Query Interactor Correlation
RGT2 YJR098C 0.38756
RGT2 SNZ1 0.38373
RGT2 TMA7 0.3731
RGT2 PCL2 0.36093
RGT2 YIG1 0.36038
RGT2 YPL102C 0.3574
RGT2 ARF2 0.34761
RGT2 EAF5 0.34747
RGT2 YNR068C 0.34648
RGT2 ERV2 0.34157

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RGT2 by homozygous co-sensitivity:

Query Interactor Correlation
RGT2 SAM2 0.62201
RGT2 YLR287C 0.61246
RGT2 BIT61 0.6108
RGT2 YUH1 0.6103
RGT2 YNL305C 0.59938
RGT2 YBR239C 0.59858
RGT2 MAL12 0.59162
RGT2 BSC5 0.58833
RGT2 YAL061W 0.58201
RGT2 MNN1 0.58171

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL138W

Other databases:

Visit YDL138W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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