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Yeast Fitness
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YDL137W / ARF2



Section 1: Phenotypes.
Gene-drug relationships for YDL137W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL137W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ARF2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 9.60868 2.3864e-08
miconazole 100 uM 5.34034 1.3194e-06
fenpropimorph 4.7 uM 5.08835 3.118e-06
clozapine 500 uM 4.94344 5.0913e-06
itraconazole 17.7 uM 4.07718 8.73e-05
bithionol 75 uM 3.64515 0.00033325
latrunculin 6.25 uM 3.59131 0.0012218
5-fluorocytosine 15.6 uM 3.50303 0.00051031
caspofungin 10 nM 3.43574 0.00062268
caspofungin 10 nM 3.40849 0.00067458

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ARF2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cadmium chloride 7.81 uM 6.38506 1.3677e-07
zncl2 1875 uM 4.88849 1.1975e-05
rapamycin 6 nM 3.98095 0.00017099
ph4 7.5 3.913 0.00050973
sodium fluoride 20000 uM 3.75839 0.00032171
synthetic complete for BY4743 0 3.30512 0.0039722
synthetic complete for BY4743 0 3.1299 0.0053462
nystatin 10 uM 3.02786 0.0063617
fk506 0.1 ug/ml 2.96758 0.0027319
dmaec 240000 uM 2.95827 0.0042072

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL137W

Top 10 functional gene interactors with YDL137W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ARF2 by heterozygous co-sensitivity:

Query Interactor Correlation
ARF2 USO1 0.44185
ARF2 RRP6 0.4139
ARF2 TKL2 0.40078
ARF2 YJL032W 0.40034
ARF2 VMA4 0.39384
ARF2 OPY2 0.39349
ARF2 MYO2 0.38756
ARF2 SNT309 0.3844
ARF2 MTF1 0.38378
ARF2 ILM1 0.38162

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ARF2 by homozygous co-sensitivity:

Query Interactor Correlation
ARF2 YJR098C 0.66154
ARF2 DCI1 0.6048
ARF2 YNL305C 0.59538
ARF2 DAN1 0.59209
ARF2 NPR2 0.58155
ARF2 YDR340W 0.5629
ARF2 MAL32 0.55626
ARF2 YJR100C 0.55565
ARF2 SCW11 0.5524
ARF2 YDR095C 0.55047

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL137W

Other databases:

Visit YDL137W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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