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Yeast Fitness
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YDL131W / LYS21



Section 1: Phenotypes.
Gene-drug relationships for YDL131W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL131W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for LYS21 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 4.93481 0.0021707
dyclonine 500 uM 4.58446 0.00031379
fk506 0.1 ug/ml 4.08208 0.00013897
itraconazole 17.7 uM 3.99018 0.0001149
fk506 0.1 ug/ml 3.59072 0.00054429
ketoconazole 11.8 uM 3.40075 0.0018272
methotrexate 500 uM 3.39519 0.00092323
haloperidol 250 uM 3.28522 0.0032584
thiabendazole 250 uM 3.17916 0.0013068
itraconazole 17.7 uM 2.98457 0.0022478

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for LYS21 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 2.94349 0.0029064
sodium fluoride 20000 uM 2.26131 0.015126
ph4 7.5 2.1132 0.024405
synthetic complete for BY4743 0 2.06926 0.032683
lysine dropout 0 2.06456 0.027283
mechlorethamine 62.5 uM 2.06342 0.024595
synthetic complete for BY4743 0 2.05903 0.033247
synthetic complete for BY4743 0 1.90936 0.042648
methotrexate 250 uM 1.90254 0.034116
bcs 200 uM 1.69288 0.051215

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL131W

Top 10 functional gene interactors with YDL131W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with LYS21 by heterozygous co-sensitivity:

Query Interactor Correlation
LYS21 RAD2 0.48054
LYS21 SPS2 0.43749
LYS21 CYM1 0.41796
LYS21 ITR1 0.41538
LYS21 TDH2 0.41491
LYS21 ATP20 0.40454
LYS21 HIS6 0.3894
LYS21 ZEO1 0.38826
LYS21 LEU3 0.38629
LYS21 MMS4_p 0.38121

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with LYS21 by homozygous co-sensitivity:

Query Interactor Correlation
LYS21 FRE6 0.6309
LYS21 YLR287C 0.62491
LYS21 SUE1 0.57103
LYS21 YFR045W 0.54751
LYS21 HOT1 0.53637
LYS21 UBX7 0.53582
LYS21 TIM21 0.5332
LYS21 DCI1 0.53061
LYS21 YDR133C 0.52818
LYS21 PRM9 0.52566

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL131W

Other databases:

Visit YDL131W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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