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YDL111C / RRP42



Section 1: Phenotypes.
Gene-drug relationships for YDL111C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL111C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RRP42 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.4 uM 11.0379 < 1e-12
5-fluorocytosine 15.6 uM 8.77862 1.0626e-11
fluconazole 31.25 uM 8.45624 2.8406e-11
5-fluorocytosine 15.6 uM 7.88996 1.8762e-10
amphotericin b 0.31 uM 6.87029 6.4311e-09
5-fluorocytosine 15.6 uM 6.86556 6.5383e-09
5-fluorouridine 23.8 uM 6.57851 1.7838e-08
amphotericin b 0.62 uM 6.50078 2.3411e-08
5-fluorouracil 19.2 uM 6.48858 1.3293e-07
5-fluorocytosine 15.6 uM 6.43813 2.9146e-08

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YDL111C

Top 10 functional gene interactors with YDL111C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RRP42 by heterozygous co-sensitivity:

Query Interactor Correlation
RRP42 DIS3 0.56956
RRP42 NOP2 0.48788
RRP42 RRP46 0.47559
RRP42 MTR3 0.46439
RRP42 NOP4 0.45591
RRP42 RRP45 0.43598
RRP42 RLP7 0.43499
RRP42 MAK21 0.42915
RRP42 MAS2 0.40203
RRP42 MRT4 0.3941

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDL111C

Other databases:

Visit YDL111C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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