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Yeast Fitness
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YDL095W / PMT1



Section 1: Phenotypes.
Gene-drug relationships for YDL095W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL095W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PMT1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 12.8487 1.1252e-08
ketoconazole 11.8 uM 8.69054 9.3203e-08
nocodazole 2 ug/ml 8.38199 3.61e-11
miconazole 0.2 uM 8.26384 1.8155e-07
tunicamycin 0.15 uM 4.33435 0.00025632
5-fluorocytosine 15.6 uM 3.77529 0.0002241
cloxyquin 15.6 uM 3.15402 0.001403
amphotericin b 0.31 uM 2.43872 0.0092859
indirubin 100 uM 2.10036 0.021833
nitromide 1000 uM 2.03657 0.023674

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for PMT1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 9.52949 0.0054166
rapamycin 9 nM 8.32957 0.0070544
ph4 7.5 7.54226 2.8065e-07
rapamycin 4.88 nM 6.95671 2.5361e-08
latrunculin 0.78 uM 6.85106 0.010324
rapamycin 6 nM 6.61565 6.9104e-08
hygromycin 13.75 uM 6.30539 1.7329e-07
cantharidin 200 uM 5.41975 2.4468e-06
k2cr2o7 125 uM 5.33808 3.1251e-06
calyculin a 2.5 uM 4.8606 1.3011e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL095W

Top 10 functional gene interactors with YDL095W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with PMT1 by heterozygous co-sensitivity:

Query Interactor Correlation
PMT1 PTC1 0.46387
PMT1 SIR3 0.46066
PMT1 MAM33 0.45343
PMT1 POL32 0.44714
PMT1 APC11 0.44577
PMT1 CTF13 0.44289
PMT1 PCP1 0.44237
PMT1 YKL037W 0.42149
PMT1 HSP42 0.40163
PMT1 UME6 0.39006

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with PMT1 by homozygous co-sensitivity:

Query Interactor Correlation
PMT1 OPI6 0.67293
PMT1 CWH41 0.56439
PMT1 CWH43 0.52163
PMT1 YAL056C-A 0.51691
PMT1 YJL171C 0.46556
PMT1 ALG8 0.45918
PMT1 ROT2 0.45897
PMT1 ALG6 0.45282
PMT1 CNE1 0.43407
PMT1 OST3 0.42329

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YDL095W

Other databases:

Visit YDL095W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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