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Yeast Fitness
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YDL088C / ASM4



Section 1: Phenotypes.
Gene-drug relationships for YDL088C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL088C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ASM4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 20.9944 3.9548e-11
nocodazole 2 ug/ml 9.26749 3.3829e-12
ketoconazole 11.8 uM 9.00603 5.7732e-08
no drug minimal media 0 7.06624 0.00020118
miconazole 0.2 uM 7.03595 1.4066e-06
alverine citrate 500 uM 4.78987 0.020465
wiskostatin 29 uM 4.6639 2.6321e-05
alverine citrate 500 uM 4.63737 0.021745
cantharidin 250 uM 4.5072 0.022932
alverine citrate 500 uM 4.16949 0.00065032

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ASM4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 100 mM 5.77928 8.8831e-06
23 degrees C 0 4.77759 0.00037422
37 degrees C 0 4.34727 9.4065e-05
psoralen 0.5 uM 4.13864 0.00030843
licl 100 mM 4.13348 0.00031199
hydroxyurea 25000 uM 3.81722 0.0002725
psoralen 0.5 uM 3.30231 0.0019805
bisphenol 125 uM 3.13598 0.0028556
licl 100 mM 3.04938 0.0034509
cantharidin disodium 100 uM 2.8358 0.0038224

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL088C

Top 10 functional gene interactors with YDL088C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ASM4 by heterozygous co-sensitivity:

Query Interactor Correlation
ASM4 COQ10 0.52641
ASM4 SNO1 0.51515
ASM4 ATS1 0.49063
ASM4 ADE1 0.47412
ASM4 CPR6 0.46795
ASM4 MCK1 0.45747
ASM4 YPT7 0.44299
ASM4 YDL086W 0.43578
ASM4 SAP155 0.43194
ASM4 YGL059W 0.41956

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ASM4 by homozygous co-sensitivity:

Query Interactor Correlation
ASM4 PHD1 0.40588
ASM4 YNL109W 0.3896
ASM4 LTP1 0.38839
ASM4 TMA20 0.38424
ASM4 RPL8B 0.38071
ASM4 PMT5 0.37754
ASM4 RSA3 0.36666
ASM4 MDV1 0.36082
ASM4 MTH1 0.35909
ASM4 YHR003C 0.35741

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:




External information about YDL088C

Other databases:

Visit YDL088C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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