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YDL075W / RPL31A



Section 1: Phenotypes.
Gene-drug relationships for YDL075W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL075W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL31A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 2.49542 0.011947
tunicamycin 0.15 uM 1.05687 0.15313
hygromycin 0.4 uM 0.654203 0.26114
floxuridine 3.37 uM 0.581578 0.28448
23 degrees C 0 0.467145 0.32335
miconazole 50 nM 0.145533 0.44305
5-fluorouracil 38.5 uM 0.142654 0.44417
nocodazole 6.6 uM 0.104078 0.4592
mitotane 100 uM 0.0173829 0.4931

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL31A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 6.98614 7.9767e-07
licl 100 mM 2.40209 0.013655
latrunculin 0.78 uM 1.80659 0.043787
aureobasidin a 0.02 ug/ml 1.6351 0.059698
bleomycin 1.7 ug/ml 1.29254 0.10626
papuamide b 0.7 ug/ml 1.21819 0.11944
bisphenol 125 uM 1.16313 0.12998
benomyl 10 ug/ml 1.1443 0.13374
bleomycin 1.13 ug/ml 0.640501 0.26496
no drug irradiated 0 0.613972 0.27346

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL075W

Top 10 functional gene interactors with YDL075W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL31A by heterozygous co-sensitivity:

Query Interactor Correlation
RPL31A YEF1 0.84996
RPL31A YDL026W 0.80246
RPL31A MNN4_p 0.78981
RPL31A HUA2 0.78119
RPL31A REC102 0.7655
RPL31A AGA1 0.7567
RPL31A EUG1 0.74366
RPL31A YJR030C 0.71238
RPL31A RPS30B 0.69215
RPL31A MSL5 0.66747

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YDL075W

Other databases:

Visit YDL075W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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