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Yeast Fitness
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YDL066W / IDP1



Section 1: Phenotypes.
Gene-drug relationships for YDL066W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL066W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for IDP1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 4.39094 0.024075
cantharidin 250 uM 4.1541 0.026677
cantharidin 250 uM 3.66829 0.033469
cantharidin 250 uM 3.59859 0.034645
cantharidin 250 uM 3.57356 0.035082
nocodazole 2 ug/ml 3.53668 0.00046167
alverine citrate 500 uM 3.11203 0.044798
cantharidin 250 uM 3.10563 0.044958
ketoconazole 11.8 uM 2.89141 0.0053144
caspofungin 10 nM 2.77876 0.0039095

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for IDP1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 39.0569 0.00032745
rapamycin 9 nM 22.3913 0.00099429
latrunculin 0.78 uM 20.428 0.0011939
mitomycin c 1000 uM 14.3275 < 1e-12
sodium sulfate 625 uM 14.1873 < 1e-12
rapamycin 6 nM 14.0086 < 1e-12
mechlorethamine 62.5 uM 14.0016 0.0025311
rapamycin 9 nM 13.4269 0.0027506
latrunculin 0.78 uM 13.4213 0.00044714
licl 100 mM 13.1656 5.5955e-11

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL066W

Top 10 functional gene interactors with YDL066W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with IDP1 by heterozygous co-sensitivity:

Query Interactor Correlation
IDP1 YBR238C 0.55518
IDP1 YOR378W 0.53776
IDP1 YGL176C 0.51942
IDP1 YOL083W 0.51858
IDP1 ECM40 0.50843
IDP1 YGR126W 0.50324
IDP1 YNL155W 0.49614
IDP1 ALG5 0.4945
IDP1 CKI1 0.49429
IDP1 GYP6 0.49316

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with IDP1 by homozygous co-sensitivity:

Query Interactor Correlation
IDP1 MET32 0.62979
IDP1 NAB6 0.59374
IDP1 YJR142W 0.59074
IDP1 SHE1 0.58422
IDP1 YKL033W-A 0.57483
IDP1 YBR027C 0.52701
IDP1 YGR106C 0.50567
IDP1 LDB7 0.50341
IDP1 DAL82 0.49469
IDP1 YIM1 0.49247

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YDL066W

Other databases:

Visit YDL066W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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