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Yeast Fitness
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YDL020C / RPN4



Section 1: Phenotypes.
Gene-drug relationships for YDL020C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL020C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPN4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 6.79799 5.5043e-08
clotrimazole 1 uM 6.00439 1.3254e-07
itraconazole 8.8 uM 4.31584 4.0631e-05
anisomycin 62.5 uM 4.08707 8.4606e-05
itraconazole 4.4 uM 3.88772 0.0001583
itraconazole 8.8 uM 3.40117 0.0006892
itraconazole 8.8 uM 3.35795 0.00078192
bufexamac 1000 uM 3.25952 0.0010392
cantharidin 200 uM 3.23725 0.001404
tunicamycin 0.15 uM 3.21231 0.011834

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPN4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
rapamycin 9 nM 11.6184 0.0036634
latrunculin 0.78 uM 10.5808 0.0044072
latrunculin 0.78 uM 8.81827 2.9804e-08
licl 100 mM 6.39408 2.5398e-06
papuamide b 0.7 ug/ml 5.85805 7.5459e-06
latrunculin 3 uM 5.32925 2.2891e-05
benomyl 10 ug/ml 4.41013 0.0001689
benomyl 10 ug/ml 4.30454 0.011538
rapamycin 9 nM 4.27824 0.025265
licl 100 mM 4.27798 0.00022634

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YDL020C

Top 10 functional gene interactors with YDL020C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPN4 by heterozygous co-sensitivity:

Query Interactor Correlation
RPN4 YJL007C 0.49407
RPN4 REH1 0.49216
RPN4 HFA1 0.48865
RPN4 HXT3 0.46656
RPN4 DIN7 0.46492
RPN4 YDR061W 0.46286
RPN4 YNL155W 0.46013
RPN4 YMD8 0.4593
RPN4 VPS54 0.45695
RPN4 COX8 0.45162

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPN4 by homozygous co-sensitivity:

Query Interactor Correlation
RPN4 UBP15 0.39777
RPN4 YER087W 0.38912
RPN4 RPL34B 0.37063
RPN4 IMG2 0.36938
RPN4 HNT3 0.36612
RPN4 YAF9 0.35933
RPN4 SMI1 0.35678
RPN4 HMT1 0.34878
RPN4 SWR1 0.34851
RPN4 LSM6 0.34851

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YDL020C

Other databases:

Visit YDL020C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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