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YDL008W / APC11

Section 1: Phenotypes.
Gene-drug relationships for YDL008W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL008W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for APC11 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 500 uM 5.66234 1.4456e-06
nocodazole 2 ug/ml 4.36649 3.4475e-05
amphotericin b 0.31 uM 3.77834 0.00022201
miconazole 50 nM 3.23536 0.0035739
wiskostatin 29 uM 3.03179 0.0023945
amphotericin b 0.31 uM 2.89484 0.0028687
thiabendazole 250 uM 2.67497 0.0051254
lovastatin 77.2 uM 2.64667 0.0055125
lovastatin 62.5 uM 2.62239 0.005866
caspofungin 10 nM 2.49221 0.0081393

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YDL008W

Top 10 functional gene interactors with YDL008W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with APC11 by heterozygous co-sensitivity:

Query Interactor Correlation
APC11 DBP10 0.63069
APC11 CTF13 0.61691
APC11 SLM3 0.61404
APC11 YDL068W 0.59318
APC11 SRM1 0.58818
APC11 HYM1 0.57807
APC11 PSA1 0.57079
APC11 MPS1 0.56361
APC11 EOS1 0.55641
APC11 CAF17 0.53522

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YDL008W

Other databases:

Visit YDL008W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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