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Yeast Fitness

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YDL003W / MCD1

Section 1: Phenotypes.
Gene-drug relationships for YDL003W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YDL003W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MCD1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 52.1677 2.4467e-08
no drug minimal media 0 50.1402 2.9821e-08
no drug minimal media 0 46.4636 4.3608e-08
no drug minimal media 0 46.1738 4.4992e-08
no drug minimal media 0 43.9339 5.7661e-08
no drug minimal media 0 38.8067 9.7791e-09
no drug minimal media 0 38.2268 1.07e-08
no drug minimal media 0 21.403 3.393e-07
no drug minimal media 0 21.3934 3.4021e-07
alverine citrate 500 uM 8.88806 6.2992e-07

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YDL003W

Top 10 functional gene interactors with YDL003W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with MCD1 by heterozygous co-sensitivity:

Query Interactor Correlation
MCD1 MTG1 0.61096
MCD1 YMR293C 0.57069
MCD1 CPR7 0.5667
MCD1 RIO2 0.56198
MCD1 YBR124W 0.55365
MCD1 ATP12 0.54891
MCD1 RIB4 0.54497
MCD1 SDH3 0.54293
MCD1 YLR458W 0.54074
MCD1 YOR060C 0.53897

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YDL003W

Other databases:

Visit YDL003W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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