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Yeast Fitness
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YCR067C / SED4



Section 1: Phenotypes.
Gene-drug relationships for YCR067C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCR067C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SED4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
drofenine hydrochloride 750 uM 9.37528 2.8555e-12
latrunculin 3.91 uM 9.05105 1.2257e-10
dyclonine 500 uM 6.83441 9.0596e-06
itraconazole 4.4 uM 6.47637 2.5497e-08
clozapine 500 uM 5.9948 1.3705e-07
metergoline 250 uM 4.54355 1.9315e-05
wiskostatin 29 uM 4.26162 8.3518e-05
dyclonine 500 uM 3.8137 0.0012338
latrunculin 1.95 uM 3.719 0.0003829
methotrexate 250 uM 3.52257 0.00065508

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for SED4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lovastatin 154.5 uM 8.75252 1.5738e-09
zncl2 1875 uM 7.38458 7.3181e-09
mitomycin c 1000 uM 7.26986 5.0693e-08
mechlorethamine 62.5 uM 5.75219 2.3381e-06
miconazole 50 nM 5.08939 1.3274e-05
cisplatin 125 uM 4.4219 7.7281e-05
mechlorethamine 62.5 uM 4.04821 0.027974
mechlorethamine 62.5 uM 3.79575 0.031463
cisplatin 125 uM 3.79209 0.00040108
amphotericin b 0.31 uM 3.78504 0.00040846

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCR067C

Top 10 functional gene interactors with YCR067C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SED4 by heterozygous co-sensitivity:

Query Interactor Correlation
SED4 YOR029W 0.47876
SED4 UBC11 0.47692
SED4 ADI1 0.45483
SED4 YBR099C 0.43118
SED4 CTF3 0.42801
SED4 YVC1_p 0.41691
SED4 STB6 0.41081
SED4 SMY1 0.40839
SED4 YAF9 0.40552
SED4 DAN3 0.40403

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with SED4 by homozygous co-sensitivity:

Query Interactor Correlation
SED4 PEX11 0.66732
SED4 ATH1 0.64265
SED4 CPR4 0.63706
SED4 YLR072W 0.63404
SED4 PRS4 0.61645
SED4 FRM2 0.61445
SED4 SLP1 0.60527
SED4 UGA4 0.605
SED4 YLR104W 0.60317
SED4 YPL067C 0.60215

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YCR067C

Other databases:

Visit YCR067C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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