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Yeast Fitness
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YCR021C / HSP30



Section 1: Phenotypes.
Gene-drug relationships for YCR021C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCR021C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HSP30 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
leucovorin 500 uM 16.3905 < 1e-12
dmso 4% 4 uM 8.33674 4.1844e-11
terbinafine 7.2 uM 5.89313 3.6652e-05
nocodazole 2 ug/ml 5.79084 2.7857e-07
fk506 0.05 ug/ml 4.94839 1.1543e-05
sanguinarine sulfate 250 uM 4.61758 1.5127e-05
tryptanthrin 250 uM 4.33597 6.7553e-05
dyclonine 500 uM 4.13657 7.228e-05
dyclonine 500 uM 4.07041 0.00077623
haloperidol 250 uM 3.74747 0.0013919

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HSP30 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cadmium chloride 7.81 uM 9.04638 7.1168e-11
ph4 7.5 4.09535 0.00033961
synthetic complete for BY4743 0 3.73215 0.032442
synthetic complete for BY4743 0 3.04205 0.0466
carboplatin 700 uM 2.97301 0.0040748
synthetic complete for BY4743 0 2.78396 0.034382
synthetic complete for BY4743 400 uM 2.68362 0.0078513
angelicin 62.5 uM 2.48297 0.011555
threonine dropout 0 2.40658 0.013877
synthetic complete for BY4743 0 2.3075 0.021847

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCR021C

Top 10 functional gene interactors with YCR021C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HSP30 by heterozygous co-sensitivity:

Query Interactor Correlation
HSP30 SIP2 0.62916
HSP30 MOH1 0.6131
HSP30 YCR099C 0.60029
HSP30 YPR115W 0.58786
HSP30 YCR023C 0.57864
HSP30 MTL1 0.53698
HSP30 YCR016W 0.51365
HSP30 YPR114W 0.5106
HSP30 FLO8_p 0.50124
HSP30 ALG3 0.50023

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with HSP30 by homozygous co-sensitivity:

Query Interactor Correlation
HSP30 MGA1 0.72246
HSP30 DMC1 0.72232
HSP30 FMP43 0.71689
HSP30 SIP5 0.71472
HSP30 AZR1 0.70381
HSP30 YCR023C 0.70206
HSP30 OSW1 0.70039
HSP30 YCR102W-A 0.69713
HSP30 ADH4 0.69701
HSP30 YOR111W 0.68372

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None




External information about YCR021C

Other databases:

Visit YCR021C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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