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YCL040W / GLK1



Section 1: Phenotypes.
Gene-drug relationships for YCL040W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCL040W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GLK1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 5.66842 1.4203e-06
resveratrol 2000 uM 5.66561 1.4319e-06
cuso4 10000 uM 4.83597 1.5996e-05
latrunculin 1.95 uM 4.41787 5.3437e-05
dna protein kinase inhibitor 0 3.65214 0.00046015
dihydromotuporamine C 7.5 uM 3.55281 0.00060346
methotrexate 250 uM 3.54721 0.00044738
clozapine 500 uM 3.47443 0.00055548
norcantharidin 2500 uM 3.44945 0.0007981
methotrexate 500 uM 3.04549 0.0023117

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GLK1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cadmium chloride 7.81 uM 8.4164 3.9625e-10
carboplatin 700 uM 5.1207 3.5775e-05
synthetic complete for BY4743 0 4.7774 0.020565
nitric oxide 800 uM 4.67695 3.9428e-05
xanthohumol 6.2 uM 4.27213 7.3735e-05
cisplatin 62.5 uM 4.25397 0.00012022
synthetic complete for BY4743 0 4.20505 0.00090706
synthetic complete for BY4743 0 4.11317 0.013015
mitomycin c 1000 uM 3.95637 0.00046277
cisplatin 125 uM 3.54899 0.0007487

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCL040W

Top 10 functional gene interactors with YCL040W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GLK1 by heterozygous co-sensitivity:

Query Interactor Correlation
GLK1 RTT105 0.45933
GLK1 YGR017W 0.45113
GLK1 SEC63 0.44124
GLK1 NBP35 0.41756
GLK1 CTF19 0.41749
GLK1 YBL077W 0.41677
GLK1 RAD24 0.40767
GLK1 UBP3 0.40067
GLK1 ERV1 0.40007
GLK1 RIA1 0.39801

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with GLK1 by homozygous co-sensitivity:

Query Interactor Correlation
GLK1 GAS3 0.62431
GLK1 CAN1 0.58522
GLK1 OPT2 0.58074
GLK1 SOL1 0.57447
GLK1 CPR8 0.55188
GLK1 PRS4 0.54703
GLK1 KCC4 0.54636
GLK1 SSK22 0.54553
GLK1 PRR2 0.53877
GLK1 GUT2 0.53166

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YCL040W

Other databases:

Visit YCL040W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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