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YCL038C / ATG22



Section 1: Phenotypes.
Gene-drug relationships for YCL038C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCL038C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ATG22 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 5.06632 3.36e-06
lapachol 500 uM 5.03097 3.7876e-06
itraconazole 17.7 uM 5.00155 4.1841e-06
latrunculin 6.25 uM 4.88106 8.3239e-05
cantharidin 250 uM 4.8359 0.0201
thiabendazole 250 uM 4.83497 7.3319e-06
fluconazole 65.3 uM 4.71517 1.0941e-05
drofenine hydrochloride 750 uM 4.64614 1.3762e-05
itraconazole 17.7 uM 4.63989 1.405e-05
methotrexate 500 uM 4.57598 3.3921e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ATG22 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 62.5 uM 11.8883 0.0035007
zncl2 1875 uM 8.74586 1.6042e-10
rapamycin 9 nM 8.40498 0.006931
wiskostatin 29 uM 5.52457 1.7873e-06
tryptophan dropout 0 4.80208 0.00036069
licl 100 mM 4.12915 0.00031501
synthetic complete for BY4743 0 4.00218 0.013984
latrunculin 3 uM 3.98789 0.0004314
rapamycin 6 nM 3.8104 0.0002778
synthetic complete for BY4743 0 3.76003 0.032008

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCL038C

Top 10 functional gene interactors with YCL038C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ATG22 by heterozygous co-sensitivity:

Query Interactor Correlation
ATG22 FRE3 0.45089
ATG22 ITT1 0.42915
ATG22 VPS13 0.42595
ATG22 YLR460C 0.41891
ATG22 YLR434C 0.41501
ATG22 MPA43 0.41439
ATG22 RIF2 0.41239
ATG22 PCK1 0.41075
ATG22 HAA1 0.40714
ATG22 YIP3 0.39686

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ATG22 by homozygous co-sensitivity:

Query Interactor Correlation
ATG22 RPL41B 0.65568
ATG22 ISF1 0.63845
ATG22 OSW1 0.62021
ATG22 YPL107W 0.61117
ATG22 HSP30 0.60807
ATG22 YNL274C 0.60118
ATG22 YCR102W-A 0.5987
ATG22 YGL260W 0.59741
ATG22 DMC1 0.59611
ATG22 FMP43 0.58912

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YCL038C

Other databases:

Visit YCL038C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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