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Yeast Fitness
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YCL028W / RNQ1



Section 1: Phenotypes.
Gene-drug relationships for YCL028W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCL028W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RNQ1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 13.4471 1.944e-10
miconazole 0.2 uM 12.2557 7.5749e-10
nocodazole 2 ug/ml 6.52537 2.1482e-08
tunicamycin 0.15 uM 5.65547 1.7902e-05
dyclonine 500 uM 5.05595 0.00014086
methotrexate 125 uM 4.60445 3.1248e-05
alverine citrate 500 uM 4.14964 0.00067372
dyclonine 500 uM 3.96179 0.00012561
AG 957 (Biomol) 500 uM 3.85958 0.00025938
methotrexate 500 uM 3.81859 0.00029069

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RNQ1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 8.83185 2.4506e-06
latrunculin 0.78 uM 6.62654 0.011012
sorbitol 1.5e+06 uM 4.79322 2.9003e-05
methotrexate 250 uM 4.3382 9.6338e-05
sorbitol 1.5e+06 uM 4.17725 0.00031595
ph8 0 3.63226 0.00060519
allyl disulfide 0.06 % 3.60785 0.00049019
minimal media 0 3.57448 0.0011673
minimal media 0 3.49637 0.00085596
latrunculin 0.78 uM 3.47105 0.036958

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCL028W

Top 10 functional gene interactors with YCL028W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RNQ1 by heterozygous co-sensitivity:

Query Interactor Correlation
RNQ1 STB3 0.45017
RNQ1 HSP30 0.45014
RNQ1 YCR001W 0.43809
RNQ1 ATG8 0.43499
RNQ1 YCL013W_d 0.42948
RNQ1 RER1 0.42666
RNQ1 CIT2 0.42629
RNQ1 CWH43 0.41952
RNQ1 FET3 0.41909
RNQ1 PRD1 0.4131

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RNQ1 by homozygous co-sensitivity:

Query Interactor Correlation
RNQ1 CRF1 0.58903
RNQ1 YCL013W_d 0.54673
RNQ1 MCH1 0.51888
RNQ1 YCR006C 0.50776
RNQ1 YDR250C 0.49423
RNQ1 YBL029W 0.48817
RNQ1 FUS1 0.47585
RNQ1 ALD2 0.47277
RNQ1 YDR185C 0.47223
RNQ1 YCL042W 0.47119

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YCL028W

Other databases:

Visit YCL028W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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