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YCL007C / YCL007C



Section 1: Phenotypes.
Gene-drug relationships for YCL007C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YCL007C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for YCL007C Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
doxorubicin 62.5 uM 13.1324 < 1e-12
nocodazole 2 ug/ml 12.5559 < 1e-12
calyculin a 2.5 uM 10.9511 < 1e-12
daunorubicin 125 uM 7.04833 3.4538e-09
ketoconazole 11.8 uM 6.69308 2.5823e-06
clotrimazole 1 uM 6.68488 1.2297e-08
caspofungin 10 nM 6.60925 1.602e-08
caspofungin 10 nM 6.27834 5.0952e-08
caspofungin 10 nM 6.26798 5.283e-08
dmso 4% 4 uM 6.06873 1.0591e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for YCL007C Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 7.70578 0.0022713
synthetic complete for BY4743 0 7.51337 6.7885e-05
synthetic complete for BY4743 0 7.32153 7.989e-05
potassium disulfite 2500 uM 5.54526 1.4489e-05
synthetic complete for BY4743 0 5.01841 0.0020203
latrunculin 0.78 uM 4.59169 0.00011317
synthetic complete for BY4743 0 4.49855 0.0032041
curcumin 150 uM 4.32221 0.0002052
synthetic complete for BY4743 0 4.22225 0.0019628
ph4 7.5 4.20016 0.00026901

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YCL007C

Top 10 functional gene interactors with YCL007C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with YCL007C by heterozygous co-sensitivity:

Query Interactor Correlation
YCL007C VMA5 0.49967
YCL007C VMA7 0.46604
YCL007C CUP5 0.45402
YCL007C RET2 0.41556
YCL007C SEC26 0.4046
YCL007C SPC42 0.39915
YCL007C PMR1 0.39768
YCL007C MSS4 0.39481
YCL007C YKL036C 0.39358
YCL007C RMD9 0.38234

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YCL007C

Other databases:

Visit YCL007C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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