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Yeast Fitness

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YBR279W / PAF1

Section 1: Phenotypes.
Gene-drug relationships for YBR279W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR279W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for PAF1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cocl2 1250 uM 7.64778 5.127e-09
aphidicolin glycinate 125 uM 6.898 4.1469e-08
latrunculin 3.91 uM 5.75234 1.1129e-06
dyclonine 500 uM 5.5682 6.1087e-05
benfluorex hydrochloride 250 uM 5.47913 2.4635e-06
mpp+ 500 ug/ml 5.34527 3.6377e-06
dna protein kinase inhibitor 0 5.12479 6.9118e-06
aureobasidin a 0.02 ug/ml 5.07291 8.0379e-06
benomyl 6.9 uM 4.96663 0.002112
chloroxine 3.91 uM 4.90526 1.3083e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for PAF1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.7568 1.4366e-09
nocodazole 10 ug/ml 9.28971 1.3706e-08
ph4 7.5 6.36358 2.6994e-06
curcumin 150 uM 5.72229 1.0001e-05
licl 100 mM 5.10405 3.708e-05
papuamide b 0.7 ug/ml 4.16731 0.00028939
myriocin 0.2 ug/ml 3.73335 0.00076067
nocodazole 10 ug/ml 3.70019 0.00081898
latrunculin 0.78 uM 3.67072 0.00087454
licl 100 mM 3.57985 0.0010705

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YBR279W

Top 10 functional gene interactors with YBR279W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with PAF1 by heterozygous co-sensitivity:

Query Interactor Correlation
PAF1 PMP1 0.55488
PAF1 YIH1 0.55247
PAF1 DPB3 0.53484
PAF1 BUD31 0.53384
PAF1 PHO87 0.53078
PAF1 PCA1 0.5279
PAF1 PER1 0.52326
PAF1 HTL1 0.52153
PAF1 RAD18 0.51955
PAF1 YCR050C 0.51763

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YBR279W

Other databases:

Visit YBR279W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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