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Yeast Fitness
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YBR278W / DPB3



Section 1: Phenotypes.
Gene-drug relationships for YBR278W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR278W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DPB3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 3.91 uM 20.524 < 1e-12
wiskostatin 29 uM 17.7089 < 1e-12
cocl2 1250 uM 14.1417 < 1e-12
dyclonine 500 uM 12.5211 1.5036e-08
benfluorex hydrochloride 250 uM 12.5048 < 1e-12
dyclonine 500 uM 12.2939 1.8458e-08
aphidicolin glycinate 125 uM 10.5595 2.9425e-12
benomyl 13.8 uM 9.26128 0.00012335
wortmannin 50 uM 7.70129 4.4269e-09
lovastatin 62.5 uM 7.54276 6.193e-10

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DPB3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
latrunculin 0.78 uM 9.37869 0.0055893
synthetic complete for BY4743 0 9.08507 0.0014087
latrunculin 0.78 uM 7.62165 0.0023443
acriflavinium hydrochloride 250 uM 3.68395 0.00053
allyl disulfide 0.06 % 3.48577 0.0006868
chlorambucil 250 uM 3.36479 0.00095538
papuamide b 1 ug/ml 3.29253 0.0011611
cantharidin analog 250 ug/ml 3.26427 0.0012526
wiskostatin 29 uM 3.22223 0.0014016
sodium sulfate 625 uM 3.19773 0.001496

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR278W

Top 10 functional gene interactors with YBR278W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DPB3 by heterozygous co-sensitivity:

Query Interactor Correlation
DPB3 SLM5 0.79871
DPB3 LCB1 0.78655
DPB3 MRPL27 0.78168
DPB3 MAL33 0.78066
DPB3 YCR076C 0.77798
DPB3 YCR051W 0.77677
DPB3 YCL001W-A 0.7684
DPB3 HTL1 0.76116
DPB3 DUG2 0.75902
DPB3 NPP1 0.75588

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with DPB3 by homozygous co-sensitivity:

Query Interactor Correlation
DPB3 YBR277C 0.585
DPB3 DPB4 0.44112
DPB3 RTT107 0.42365
DPB3 YPL062W 0.38841
DPB3 RAD18 0.38497
DPB3 DUN1 0.37158
DPB3 PHO23 0.36566
DPB3 URA7 0.36378
DPB3 YNL196C 0.35855
DPB3 MRC1 0.34776

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YBR278W

Other databases:

Visit YBR278W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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