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YBR208C / DUR1,2



Section 1: Phenotypes.
Gene-drug relationships for YBR208C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR208C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for DUR1,2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 1000 uM 8.50019 2.4693e-11
fenpropimorph 4.7 uM 7.54509 6.1434e-10
mitomycin c 1000 uM 6.13926 8.2813e-08
amphotericin b 0.62 uM 5.87639 2.0694e-07
fenbendazole 500 uM 5.63184 4.8334e-07
itraconazole 17.7 uM 5.60245 5.3504e-07
amphotericin b 0.31 uM 5.43571 9.5086e-07
solasodine 250 uM 5.28326 1.6043e-06
itraconazole 17.7 uM 5.25217 1.7843e-06
bithionol 75 uM 5.15848 2.4565e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for DUR1,2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cisplatin 125 uM 12.9552 < 1e-12
mitomycin c 1000 uM 11.0631 1.242e-11
mitomycin c 1000 uM 9.81144 9.4753e-12
acriflavinium hydrochloride 250 uM 9.64244 2.2501e-10
nocodazole 10 ug/ml 9.43367 1.0868e-08
mncl2 2 mM 8.45214 3.5899e-10
latrunculin 0.78 uM 8.35208 0.0070172
acriflavinium hydrochloride 250 uM 8.33206 4.0911e-09
licl 100 mM 7.7397 1.9563e-07
cisplatin 66 uM 7.65046 2.0228e-08

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR208C

Top 10 functional gene interactors with YBR208C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with DUR1,2 by heterozygous co-sensitivity:

Query Interactor Correlation
DUR1,2 AIR1 0.46124
DUR1,2 YIL054W 0.42923
DUR1,2 BIO4 0.42636
DUR1,2 CPR8 0.41875
DUR1,2 URA1 0.40696
DUR1,2 HOS1 0.39928
DUR1,2 NDI1 0.39513
DUR1,2 HSP26 0.39199
DUR1,2 MRL1 0.38461
DUR1,2 GTR1 0.38294

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with DUR1,2 by homozygous co-sensitivity:

Query Interactor Correlation
DUR1,2 YKL121W 0.69571
DUR1,2 YDL073W 0.64125
DUR1,2 YLR232W 0.62116
DUR1,2 YOS9 0.61452
DUR1,2 SCJ1 0.54269
DUR1,2 GRE3 0.53327
DUR1,2 YLR407W 0.50732
DUR1,2 DBF2 0.49873
DUR1,2 ACF4 0.49742
DUR1,2 PSY2 0.47497

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YBR208C

Other databases:

Visit YBR208C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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