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YBR193C / MED8



Section 1: Phenotypes.
Gene-drug relationships for YBR193C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR193C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MED8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 27.7158 5.7227e-07
no drug minimal media 0 25.2893 9.0228e-07
no drug minimal media 0 21.2629 2.1327e-06
no drug minimal media 0 9.86167 9.1375e-05
no drug minimal media 0 9.73987 9.6977e-05
no drug minimal media 0 8.30449 8.264e-05
no drug minimal media 0 7.87649 0.00011089
caspofungin 10 nM 7.39857 1.0207e-09
distamycin a 250 uM 7.38399 1.0624e-08
caspofungin 10 nM 7.31743 1.3529e-09

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YBR193C

Top 10 functional gene interactors with YBR193C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MED8 by heterozygous co-sensitivity:

Query Interactor Correlation
MED8 SOY1 0.45899
MED8 COQ9 0.39718
MED8 HPR1 0.39076
MED8 YDR428C 0.38809
MED8 NMT1 0.3826
MED8 MRPS35 0.38243
MED8 SNM1 0.38066
MED8 APC4 0.37088
MED8 CDC60 0.36991
MED8 MRP10 0.36544

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YBR193C

Other databases:

Visit YBR193C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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