Retrieving results for YBR189W, please wait...

Yeast Fitness

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search


Section 1: Phenotypes.
Gene-drug relationships for YBR189W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR189W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS9B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
drofenine hydrochloride 750 uM 11.2042 < 1e-12
metergoline 250 uM 8.21084 6.3443e-11
clozapine 500 uM 7.79129 2.63e-10
pp2 100 uM 7.38066 1.0722e-08
paraquat 2000 uM 6.27588 2.4477e-07
propiomazine maleate 500 uM 6.14284 8.1785e-08
drofenine hydrochloride 750 uM 5.87799 2.0579e-07
terbinafine 7.2 uM 5.81852 4.1159e-05
fenpropimorph 2.3 uM 4.79419 0.00021892
methotrexate 250 uM 4.56096 3.5421e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS9B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 6.19714 3.7726e-06
synthetic complete for BY4743 0 5.96227 0.0047194
rapamycin 9 nM 4.99046 0.018943
rapamycin 9 nM 1.96326 0.072196
latrunculin 0.78 uM 1.84987 0.080722
benzaldehyde 0.003 % 1.76187 0.047533
bisphenol 125 uM 1.75828 0.047845
4nqo 0.0313 uM 1.488 0.07703
benomyl 10 ug/ml 1.37063 0.09367
benomyl 10 ug/ml 1.33404 0.13721

More... (click to see all Homozygous data)

Section 2: Co-fitness interactions.
Gene-gene relationships for YBR189W

Top 10 functional gene interactors with YBR189W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with RPS9B by heterozygous co-sensitivity:

Query Interactor Correlation
RPS9B RPS10A 0.59206
RPS9B RPS27B 0.58588
RPS9B RPS18A 0.58388
RPS9B RPS6A 0.58225
RPS9B RPS16B 0.58
RPS9B BUB1 0.57999
RPS9B RRP9 0.57843
RPS9B UTP6 0.57723
RPS9B RPS3 0.57316
RPS9B RPS17A 0.55919

More... (click to see all interactions)

Enriched GO terms of interactors

Homozygous co-fitness interactions

[No homozygous results.]

External information about YBR189W

Other databases:

Visit YBR189W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

Download a plain text version of this page.