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YBR181C / RPS6B



Section 1: Phenotypes.
Gene-drug relationships for YBR181C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR181C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPS6B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.5 uM 5.41076 2.8863e-05
floxuridine 3.37 uM 4.48441 0.00018773
progesterone 1000 uM 3.15169 0.012665
cantharidin 250 uM 2.77975 0.0045169
alizarin 66 uM 2.42497 0.010566
benomyl 3.4 uM 2.31507 0.034237
methotrexate 500 uM 2.2279 0.016521
norcantharidin 2500 uM 2.2153 0.016989
chemdiv 246 31 uM 2.1748 0.018573
brefeldin a 1000 uM 2.13701 0.02017

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPS6B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 7.75686 1.8964e-07
synthetic complete for BY4743 0 3.67435 0.017447
carboplatin 700 uM 2.67812 0.0076738
5-fluorouracil 38.5 uM 2.43011 0.013231
synthetic complete for BY4743 0 1.97719 0.093322
papuamide b 0.7 ug/ml 1.64922 0.058222
5-fluorouracil 19.2 uM 1.01902 0.16124
sorbitol 1.5e+06 uM 0.92819 0.18758
rapamycin 9 nM 0.927709 0.22575
no drug irradiated 0 0.867308 0.19859

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR181C

Top 10 functional gene interactors with YBR181C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPS6B by heterozygous co-sensitivity:

Query Interactor Correlation
RPS6B NAT3 0.59232
RPS6B RPS10A 0.58259
RPS6B TRR2 0.5619
RPS6B OST5 0.55892
RPS6B RSB1 0.55871
RPS6B IDH2 0.55777
RPS6B STE13 0.5506
RPS6B GCV3 0.54917
RPS6B NGL3 0.54758
RPS6B YOL083W 0.54681

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with RPS6B by homozygous co-sensitivity:

Query Interactor Correlation
RPS6B RPS11B 0.67612
RPS6B SLX9 0.64445
RPS6B RPS23A 0.6171
RPS6B RPS29B 0.58648
RPS6B RPL6A 0.56556
RPS6B YDL063C 0.5192
RPS6B RPL24B 0.51393
RPS6B RPL11B 0.51331
RPS6B FYV12 0.50617
RPS6B SSF1 0.50222

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:




External information about YBR181C

Other databases:

Visit YBR181C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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