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YBR160W / CDC28



Section 1: Phenotypes.
Gene-drug relationships for YBR160W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR160W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CDC28 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 10.0111 < 1e-12
caspofungin 10 nM 4.79853 8.2837e-06
caspofungin 10 nM 4.51781 2.1022e-05
fenpropimorph 4.7 uM 4.35276 3.6048e-05
caspofungin 10 nM 4.29677 4.3216e-05
dyclonine 500 uM 3.90607 0.0010435
clozapine 500 uM 3.85915 0.00017299
aminophenazone 250 uM 3.62363 0.00035564
fluconazole 130.6 uM 3.25944 0.0010394
mecysteine hydrochloride 62.5 uM 3.21211 0.00119

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YBR160W

Top 10 functional gene interactors with YBR160W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CDC28 by heterozygous co-sensitivity:

Query Interactor Correlation
CDC28 YJR141W 0.38068
CDC28 PEP12 0.37274
CDC28 BUD25 0.37117
CDC28 CDC2 0.34946
CDC28 EXO1 0.34032
CDC28 ZDS1 0.33269
CDC28 CIK1 0.33262
CDC28 YNL018C 0.33019
CDC28 GNA1 0.31972
CDC28 NPL4 0.31876

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YBR160W

Other databases:

Visit YBR160W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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