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Yeast Fitness

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YBR135W / CKS1

Section 1: Phenotypes.
Gene-drug relationships for YBR135W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR135W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CKS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
itraconazole 17.7 uM 3.71963 0.00026575
lapachol 1000 uM 3.41998 0.0006522
dyclonine 500 uM 3.25325 0.0034573
doxorubicin 62.5 uM 3.14903 0.0014229
5-fluorocytosine 15.6 uM 3.00021 0.0021533
licl 150 mM 2.86412 0.0036621
amphotericin b 10 uM 2.81785 0.0035253
chemdiv 218 250 uM 2.38486 0.01159
ansamitosin 500 uM 2.37873 0.011754
splitomicin 250 uM 2.31466 0.013602

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YBR135W

Top 10 functional gene interactors with YBR135W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with CKS1 by heterozygous co-sensitivity:

Query Interactor Correlation
CKS1 RRP3 0.53354
CKS1 ROM2 0.52746
CKS1 SFT1 0.51737
CKS1 ATP11 0.51106
CKS1 TMA23 0.50114
CKS1 YER087W 0.49608
CKS1 YCR064C 0.49248
CKS1 RPL3 0.4923
CKS1 RPG1 0.492
CKS1 VRP1 0.4907

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YBR135W

Other databases:

Visit YBR135W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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