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Yeast Fitness
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YBR127C / VMA2



Section 1: Phenotypes.
Gene-drug relationships for YBR127C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR127C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for VMA2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
caspofungin 10 nM 8.88985 7.8185e-12
alverine citrate 500 uM 8.28174 1.3167e-06
nocodazole 2 ug/ml 7.99186 1.326e-10
ketoconazole 11.8 uM 7.87587 3.3944e-07
miconazole 0.2 uM 7.74908 4.1819e-07
methotrexate 250 uM 7.32321 1.2579e-08
methotrexate 250 uM 7.26355 1.4854e-08
methotrexate 500 uM 7.2509 1.5388e-08
methotrexate 500 uM 6.71761 6.9157e-08
methotrexate 250 uM 5.39702 3.1288e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for VMA2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 14.8601 7.489e-07
synthetic complete for BY4743 0 13.8017 1.2372e-06
synthetic complete for BY4743 0 13.482 1.4501e-06
synthetic complete for BY4743 0 6.75899 0.00013142
synthetic complete for BY4743 0 5.68837 0.0023583
synthetic complete for BY4743 0 5.19289 0.0017438
ph8 0 4.51682 0.0005569
sorbitol 1.5e+06 uM 4.39392 0.0006739
synthetic complete for BY4743 0 4.36337 0.0036336
23 degrees C 0 4.13325 0.0010168

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR127C

Top 10 functional gene interactors with YBR127C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with VMA2 by heterozygous co-sensitivity:

Query Interactor Correlation
VMA2 UFE1 0.46146
VMA2 BUD25 0.44587
VMA2 YDR535C 0.42753
VMA2 RNT1 0.42625
VMA2 DCP1 0.39578
VMA2 IES6 0.38939
VMA2 JIP5 0.38741
VMA2 MSE1 0.38554
VMA2 MRPL22 0.38476
VMA2 NAM9 0.38225

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with VMA2 by homozygous co-sensitivity:

Query Interactor Correlation
VMA2 MRP1 0.732
VMA2 NAM2 0.71056
VMA2 RAD51 0.70622
VMA2 GLE2 0.6974
VMA2 PIH1 0.67332
VMA2 YNL296W 0.65798
VMA2 MSK1 0.65521
VMA2 SLX8 0.65199
VMA2 MSC1 0.61705
VMA2 LYS2 0.61464

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:




External information about YBR127C

Other databases:

Visit YBR127C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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