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Yeast Fitness

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YBR121C / GRS1

Section 1: Phenotypes.
Gene-drug relationships for YBR121C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR121C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GRS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
tomatine 62.5 uM 5.99578 1.3658e-07
dmso 4% 4 uM 4.3262 3.9291e-05
floxuridine 80000 uM 4.00807 0.00010861
chemdiv 41 500 uM 3.96508 0.00019315
methotrexate 250 uM 3.93895 0.00020782
rapamycin 6 nM 3.62633 0.00049385
fluconazole 130.6 uM 3.61306 0.00036717
hexestrol 125 uM 3.52035 0.00048469
fk506 100 uM 3.35734 0.0010215
hexetidine 31.25 uM 3.17603 0.0013184

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YBR121C

Top 10 functional gene interactors with YBR121C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with GRS1 by heterozygous co-sensitivity:

Query Interactor Correlation
GRS1 MTG1 0.65745
GRS1 MDM12 0.65371
GRS1 CPR7 0.63801
GRS1 BET2 0.63453
GRS1 SOH1 0.63197
GRS1 PRP40 0.63073
GRS1 USO1 0.62288
GRS1 MED11 0.61937
GRS1 YMR293C 0.6193
GRS1 YLR458W 0.61383

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YBR121C

Other databases:

Visit YBR121C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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