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YBR091C / MRS5

Section 1: Phenotypes.
Gene-drug relationships for YBR091C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR091C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MRS5 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
wiskostatin 29 uM 20.3354 < 1e-12
clozapine 500 uM 12.7531 < 1e-12
metergoline 250 uM 12.1885 < 1e-12
cloxyquin 15.6 uM 11.288 < 1e-12
fenpropimorph 4.7 uM 10.4578 < 1e-12
mitomycin c 1000 uM 10.2607 < 1e-12
trifluoperazine dihydrochloride 31.25 uM 10.2307 6.4679e-12
fenpropimorph 8 nM 9.3249 3.0785e-12
fendiline hydrochloride 125 uM 9.32368 3.0844e-12
phenanthroline monohydrochloride 62.5 uM 8.99964 1.3992e-10

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YBR091C

Top 10 functional gene interactors with YBR091C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with MRS5 by heterozygous co-sensitivity:

Query Interactor Correlation
MRS5 LSM2 0.74126
MRS5 RPL32 0.6804
MRS5 MTR4 0.67413
MRS5 GFD2 0.57333
MRS5 HSV2 0.52328
MRS5 ARP4 0.40069
MRS5 YSA1 0.39773
MRS5 MRPL16 0.39432
MRS5 FMT1 0.38305
MRS5 ACS2 0.37796

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YBR091C

Other databases:

Visit YBR091C in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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