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Yeast Fitness
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YBR090C-A / NHP6B



Section 1: Phenotypes.
Gene-drug relationships for YBR089C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR089C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for NHP6B Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 48.3564 3.573e-08
no drug minimal media 0 47.4835 3.9131e-08
no drug minimal media 0 46.1366 4.5173e-08
no drug minimal media 0 43.2254 6.2532e-08
no drug minimal media 0 40.2871 8.8836e-08
no drug minimal media 0 31.7705 3.2312e-08
no drug minimal media 0 28.8374 5.7589e-08
dyclonine 500 uM 24.0032 8.2082e-12
no drug minimal media 0 23.8352 1.7905e-07
no drug minimal media 0 23.5428 1.9269e-07

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for NHP6B Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cadmium chloride 7.81 uM 21.2142 < 1e-12
licl 100 mM 13.7007 2.9056e-11
synthetic complete for BY4743 0 11.2653 0.00074994
mncl2 2 mM 9.52469 1.9995e-11
zncl2 1875 uM 7.86041 1.8783e-09
l-dopa 12.5 ug/ml 6.2207 2.2294e-07
nocodazole 10 ug/ml 4.19655 0.00027118
mitomycin c 1000 uM 3.95864 0.00018226
fk506 0.05 ug/ml 3.91676 0.0002054
nitric oxide 800 uM 3.55495 0.00073741

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR089C-A

Top 10 functional gene interactors with YBR089C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with NHP6B by heterozygous co-sensitivity:

Query Interactor Correlation
NHP6B LYS2 0.46975
NHP6B YKL077W 0.46725
NHP6B YPL071C 0.44492
NHP6B ADE2 0.44296
NHP6B YNL115C 0.43546
NHP6B HOM6 0.42692
NHP6B YKL070W 0.42334
NHP6B PAD1 0.40629
NHP6B STB6 0.39771
NHP6B TCM62 0.3958

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with NHP6B by homozygous co-sensitivity:

Query Interactor Correlation
NHP6B PMT3 0.66526
NHP6B YJL132W 0.57494
NHP6B SGA1 0.55742
NHP6B ARN2 0.54545
NHP6B BUD8 0.5424
NHP6B TGL3 0.54136
NHP6B MLH2 0.52844
NHP6B CYM1 0.52762
NHP6B YOL029C 0.52754
NHP6B MUP3 0.52667

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YBR089C-A

Other databases:

Visit YBR089C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
    Process:
    • None
    Function:
    • None
    Component:
    • None

Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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