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Yeast Fitness
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YBR085W / AAC3



Section 1: Phenotypes.
Gene-drug relationships for YBR085W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR085W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for AAC3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 72.4692 4.7399e-09
no drug minimal media 0 67.25 6.8847e-09
no drug minimal media 0 60.675 1.1509e-08
no drug minimal media 0 57.2875 1.5332e-08
no drug minimal media 0 51.1299 2.7049e-08
no drug minimal media 0 50.2619 2.0803e-09
no drug minimal media 0 33.7902 2.2364e-08
no drug minimal media 0 32.0791 3.0501e-08
no drug minimal media 0 20.7939 4.0267e-07
clotrimazole 1 uM 11.9966 < 1e-12

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for AAC3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
nocodazole 10 ug/ml 9.41926 1.1122e-08
synthetic complete for BY4743 0 3.98193 0.0026554
synthetic complete for BY4743 0 3.30686 0.010657
carboplatin 700 uM 2.42668 0.012981
angelicin 62.5 uM 2.27562 0.017663
carboplatin 15 mM 2.0685 0.026635
sodium fluoride 20000 uM 1.87087 0.034995
synthetic complete for BY4743 0 1.82986 0.054984
mitomycin c 1 mM 1.676 0.055511
mitomycin c 1 mM 1.63433 0.059779

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR085W

Top 10 functional gene interactors with YBR085W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with AAC3 by heterozygous co-sensitivity:

Query Interactor Correlation
AAC3 YPR077C 0.71892
AAC3 YFR039C 0.6921
AAC3 CLB2 0.66869
AAC3 MFB1 0.59114
AAC3 MET14 0.57976
AAC3 ILV1 0.57329
AAC3 NAP1 0.57048
AAC3 YKL187C 0.56099
AAC3 PGM1 0.55867
AAC3 TIR1 0.55471

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with AAC3 by homozygous co-sensitivity:

Query Interactor Correlation
AAC3 UBS1 0.74061
AAC3 STO1 0.64523
AAC3 YKL066W 0.64169
AAC3 YAL061W 0.58632
AAC3 KIN1 0.56334
AAC3 RSM24 0.56221
AAC3 YTA6 0.56028
AAC3 YFL040W 0.5426
AAC3 YFL052W 0.53958
AAC3 YAL045C 0.53914

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YBR085W

Other databases:

Visit YBR085W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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