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YBR084C-A / RPL19A



Section 1: Phenotypes.
Gene-drug relationships for YBR084C-A
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR084C-A deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for RPL19A Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 7.63744 0.00030612
no drug minimal media 0 7.03325 0.00044848
fenbendazole 500 uM 5.50244 7.5565e-07
methotrexate 125 uM 5.48046 2.454e-06
no drug minimal media 0 3.5906 0.0078491
estradiol 2500 uM 3.57076 0.00041693
cantharidin disodium 100 uM 3.48587 0.00072347
phenolphthalein 250 uM 3.4026 0.00090509
estradiol 2500 uM 3.11882 0.001549
solasodine 250 uM 3.0621 0.0018148

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for RPL19A Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 12.1001 2.2072e-10
licl 100 mM 5.78369 8.8021e-06
rapamycin 9 nM 3.84267 0.030769
bisphenol 125 uM 3.11196 0.0030098
dmaec 240000 uM 2.0183 0.029358
benomyl 10 ug/ml 1.7986 0.044437
aureobasidin a 0.02 ug/ml 1.74564 0.048959
rapamycin 9 nM 1.5788 0.10625
psoralen 0.5 uM 1.25796 0.11224
dmaec 240000 uM 0.996014 0.16622

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR084C-A

Top 10 functional gene interactors with YBR084C-A. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with RPL19A by heterozygous co-sensitivity:

Query Interactor Correlation
RPL19A RPL43A 0.65176
RPL19A RPL6B 0.64021
RPL19A RPL34A 0.62772
RPL19A RPL20A 0.62724
RPL19A RPL6A 0.61137
RPL19A RPL37A 0.60892
RPL19A RPL24A 0.60821
RPL19A OPI11 0.608
RPL19A RPL12A 0.59885
RPL19A RPL40B 0.59576

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YBR084C-A

Other databases:

Visit YBR084C-A in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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