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YBR080C / SEC18



Section 1: Phenotypes.
Gene-drug relationships for YBR080C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR080C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SEC18 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
thiabendazole 250 uM 10.1206 < 1e-12
ID 693632 62.5 uM 10.0785 9.3577e-12
cloxyquin 15.6 uM 7.27266 1.5808e-09
mechlorethamine 250 uM 7.10631 2.8215e-09
bufexamac 1000 uM 5.64431 4.6293e-07
itraconazole 17.7 uM 5.55614 6.2786e-07
licl 150 mM 5.50281 2.2994e-06
bufexamac 1000 uM 5.50139 7.5838e-07
itraconazole 35.4 uM 5.28533 1.593e-06
fluconazole 65.3 uM 5.28376 1.6016e-06

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YBR080C

Top 10 functional gene interactors with YBR080C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with SEC18 by heterozygous co-sensitivity:

Query Interactor Correlation
SEC18 ECM16 0.55184
SEC18 YJL032W 0.54714
SEC18 RIB4 0.53381
SEC18 MTG1 0.52351
SEC18 PGA3 0.51554
SEC18 BUD16 0.50756
SEC18 RRN7 0.50566
SEC18 TKL2 0.50502
SEC18 SNT309 0.50359
SEC18 MYO1 0.50147

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YBR080C

Other databases:

Visit YBR080C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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