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Yeast Fitness
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YBR072W / HSP26



Section 1: Phenotypes.
Gene-drug relationships for YBR072W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR072W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HSP26 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
no drug minimal media 0 16.531 1.5621e-06
no drug minimal media 0 15.3205 2.4426e-06
no drug minimal media 0 13.1801 2.2453e-05
no drug minimal media 0 13.0982 2.3146e-05
telomerase inhibitor ix (Biomol) 500 uM 12.6648 < 1e-12
no drug minimal media 0 12.0349 3.4952e-05
no drug minimal media 0 11.6968 1.1774e-05
no drug minimal media 0 11.5193 4.3222e-05
no drug minimal media 0 9.21753 0.00012616
no drug minimal media 0 9.07287 5.0295e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HSP26 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 8.82472 1.3388e-09
nocodazole 10 ug/ml 5.11686 3.6071e-05
mechlorethamine 62.5 uM 4.41631 7.8428e-05
carboplatin 700 uM 4.08755 0.00034555
acriflavinium hydrochloride 250 uM 4.06532 0.0001971
synthetic complete for BY4743 0 4.04495 0.028016
rapamycin 9 nM 3.79814 0.031427
latrunculin 3 uM 3.76556 0.000708
methotrexate 500 uM 3.64538 0.00092528
zncl2 1875 uM 3.52837 0.00061083

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR072W

Top 10 functional gene interactors with YBR072W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HSP26 by heterozygous co-sensitivity:

Query Interactor Correlation
HSP26 UTR1 0.42354
HSP26 DUR1,2 0.39199
HSP26 YBR064W 0.38393
HSP26 BIO4 0.38379
HSP26 AIR1 0.37736
HSP26 YIR014W 0.37522
HSP26 INO4 0.37372
HSP26 YJR061W 0.36279
HSP26 HRD3 0.35665
HSP26 YDR115W 0.35373

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HSP26 by homozygous co-sensitivity:

Query Interactor Correlation
HSP26 SOL1 0.74104
HSP26 ATG16 0.70911
HSP26 CPR8 0.69244
HSP26 EDS1 0.6616
HSP26 IRC20 0.64969
HSP26 BNA4 0.62884
HSP26 GUT2 0.61432
HSP26 YNL034W 0.60981
HSP26 YBR064W 0.60772
HSP26 SDP1 0.60577

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YBR072W

Other databases:

Visit YBR072W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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