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YBR070C / ALG14



Section 1: Phenotypes.
Gene-drug relationships for YBR070C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR070C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ALG14 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
fluconazole 65.3 uM 9.47689 2.5052e-12
fluconazole 130.6 uM 7.07735 3.1213e-09
estrone acetate 1000 uM 6.77879 8.8546e-09
acriflavinium hydrochloride 250 uM 6.50585 2.3e-08
itraconazole 8.8 uM 6.07673 1.03e-07
5-fluorocytosine 15.6 uM 5.7885 2.8085e-07
trichlormethine 1000 uM 5.12024 2.7978e-06
fluconazole 31.25 uM 4.50693 2.1787e-05
flunarizine hydrochloride 93.8 uM 4.41171 2.9755e-05
miconazole 0.2 uM 4.35974 3.5239e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YBR070C

Top 10 functional gene interactors with YBR070C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ALG14 by heterozygous co-sensitivity:

Query Interactor Correlation
ALG14 FAD1 0.56628
ALG14 RMD9 0.54772
ALG14 NSE5 0.54098
ALG14 MRPL49 0.52301
ALG14 ATP12 0.50827
ALG14 MED11 0.50547
ALG14 OST1 0.50192
ALG14 SRP14 0.49956
ALG14 YRB2 0.49414
ALG14 CAF17 0.49389

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YBR070C

Other databases:

Visit YBR070C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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