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Yeast Fitness
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YBR026C / ETR1



Section 1: Phenotypes.
Gene-drug relationships for YBR026C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR026C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ETR1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
alverine citrate 500 uM 6.94412 0.010057
no drug minimal media 0 4.96947 0.0021068
cantharidin 250 uM 4.69486 0.021249
alverine citrate 500 uM 4.11511 0.027144
nocodazole 2 ug/ml 3.06128 0.0018189
methotrexate 500 uM 3.01825 0.014738
amphotericin b 0.31 uM 2.9771 0.0022942
no drug minimal media 0 2.96238 0.012602
no drug minimal media 0 2.95656 0.015822
amphotericin b 0.62 uM 2.9203 0.002678

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ETR1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
potassium disulfite 2500 uM 10.3565 2.5975e-09
synthetic complete for BY4743 0 9.59447 0.0012013
benomyl 10 ug/ml 3.54955 0.019052
rapamycin 9 nM 3.4407 0.020607
latrunculin 0.78 uM 3.25274 0.023696
latrunculin 0.78 uM 2.88453 0.051054
rapamycin 9 nM 2.79662 0.053806
synthetic complete for BY4743 0 2.27167 0.075533
bleomycin 1.7 ug/ml 2.12004 0.024079
benomyl 10 ug/ml 1.79834 0.044458

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR026C

Top 10 functional gene interactors with YBR026C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ETR1 by heterozygous co-sensitivity:

Query Interactor Correlation
ETR1 NOP8 0.4123
ETR1 YMR098C 0.38258
ETR1 MPS3_p 0.38143
ETR1 GAA1 0.37645
ETR1 MMR1 0.37111
ETR1 CTF18 0.36828
ETR1 OSW2 0.36744
ETR1 RRS1 0.36606
ETR1 ORC2 0.36321
ETR1 SHU2 0.35922

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YBR026C

Other databases:

Visit YBR026C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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