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YBR019C / GAL10



Section 1: Phenotypes.
Gene-drug relationships for YBR019C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBR019C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for GAL10 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 5.43259 9.6113e-07
methotrexate 250 uM 4.64469 1.3828e-05
latrunculin 3.91 uM 4.62639 2.9331e-05
atorvastatin 125 uM 4.04473 9.6744e-05
5-fluorocytosine 15.6 uM 3.54878 0.00044528
drofenine hydrochloride 750 uM 3.52818 0.00047352
caspofungin 10 nM 3.25097 0.001065
leucovorin 500 uM 3.13944 0.0014619
lovastatin 62.5 uM 2.91733 0.0026996
5-fluorocytosine 15.6 uM 2.85405 0.0032009

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for GAL10 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
yp glycerol 0 11.3155 2.5327e-07
yp glycerol 0 10.7384 4.1215e-07
yp glycerol 0 5.96041 7.7524e-06
yp glycerol 0 5.81744 1.0297e-05
cadmium chloride 7.81 uM 5.61889 1.3472e-06
mitomycin c 1000 uM 4.598 4.8567e-05
nocodazole 10 ug/ml 4.11915 0.00032209
methotrexate 250 uM 3.49581 0.00085718
licl 150 mM 3.34388 0.001011
berberine chloride 125 uM 3.16712 0.0019541

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBR019C

Top 10 functional gene interactors with YBR019C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with GAL10 by heterozygous co-sensitivity:

Query Interactor Correlation
GAL10 DUG1 0.36086
GAL10 PRT1 0.34954
GAL10 SVF1 0.34258
GAL10 MGA2 0.33427
GAL10 VMA2 0.31228
GAL10 WSC2 0.31013
GAL10 MLS1 0.30833
GAL10 RAM2 0.30824
GAL10 YDR535C 0.3045
GAL10 TRM82 0.30307

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with GAL10 by homozygous co-sensitivity:

Query Interactor Correlation
GAL10 YIR007W 0.66944
GAL10 YIL108W 0.6653
GAL10 YBR064W 0.65912
GAL10 IDP3 0.65675
GAL10 YNL034W 0.65496
GAL10 NRK1 0.65373
GAL10 YNL122C 0.65015
GAL10 QDR3 0.6488
GAL10 SCO2 0.64022
GAL10 GAL7 0.60936

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YBR019C

Other databases:

Visit YBR019C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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