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Yeast Fitness
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YBL042C / FUI1



Section 1: Phenotypes.
Gene-drug relationships for YBL042C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBL042C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for FUI1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 21.3687 < 1e-12
methotrexate 125 uM 16.3443 < 1e-12
5-fluorouracil 76.8 uM 15.3862 < 1e-12
floxuridine 80000 uM 14.8307 < 1e-12
sanguinarine sulfate 250 uM 12.3178 < 1e-12
sanguinarine sulfate 250 uM 10.8911 < 1e-12
5-fluorouracil 76.8 uM 10.042 1.0229e-11
methotrexate 250 uM 9.79531 1.8756e-11
methotrexate 125 uM 9.24474 7.4677e-11
methotrexate 500 uM 9.07314 1.1581e-10

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for FUI1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouracil 38.46 uM 7.26148 1.3608e-05
ph8 0 5.89326 7.6218e-05
ph8 0 5.11991 0.00022537
ph8 0 4.86959 0.000326
cisplatin 250 uM 4.76698 3.1085e-05
mechlorethamine 62.5 uM 4.68076 3.9033e-05
nystatin 10 uM 4.66843 0.00044146
mitomycin c 1000 uM 4.4621 6.9512e-05
5-fluorouracil 19.2 uM 4.33868 0.00073471
alverine citrate 500 uM 4.19178 0.00014154

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBL042C

Top 10 functional gene interactors with YBL042C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with FUI1 by heterozygous co-sensitivity:

Query Interactor Correlation
FUI1 NOP4 0.47216
FUI1 RLR1 0.43543
FUI1 YPL044C 0.41937
FUI1 MEH1 0.36137
FUI1 URA1 0.35316
FUI1 SAT4 0.35116
FUI1 RRP15 0.33004
FUI1 RRP12 0.32715
FUI1 VAC17 0.32649
FUI1 LSB5 0.30771

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with FUI1 by homozygous co-sensitivity:

Query Interactor Correlation
FUI1 URK1 0.44813
FUI1 YDR020C 0.43629
FUI1 RTF1 0.40406
FUI1 YBR053C 0.37985
FUI1 MUD1 0.37268
FUI1 PPR1 0.36772
FUI1 SWD3 0.36213
FUI1 YLR374C 0.36074
FUI1 MKS1 0.35226
FUI1 HMT1 0.34575

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:Component:
  • None




External information about YBL042C

Other databases:

Visit YBL042C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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