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Yeast Fitness
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YBL002W / HTB2



Section 1: Phenotypes.
Gene-drug relationships for YBL002W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YBL002W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for HTB2 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
distamycin a 250 uM 7.27615 1.4341e-08
streptovitacin 62.5 uM 5.90847 7.0746e-07
phloretin 500 uM 4.82816 1.6362e-05
no drug minimal media 0 4.3519 0.003673
norcantharidin 100 uM 3.87019 0.00025182
no drug minimal media 0 3.66216 0.0052761
thiolutin 7.81 uM 3.27707 0.0012641
ID 604586 31.25 uM 3.21951 0.0014711
no drug minimal media 0 3.08411 0.010775
chemdiv 41 500 uM 3.04585 0.0023096

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for HTB2 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
methotrexate 250 uM 12.6377 < 1e-12
methotrexate 250 uM 9.4751 3.2183e-10
licl 150 mM 8.31636 5.2284e-10
rapamycin 9 nM 8.31183 0.0018246
23 degrees C 0 7.98758 5.9681e-06
licl 150 mM 7.05587 1.8985e-08
fk506 0.1 ug/ml 6.91319 2.8805e-08
fk506 0.05 ug/ml 6.64405 6.3547e-08
licl 100 mM 6.29671 3.0866e-06
paraquat 5000 uM 5.70901 1.0285e-06

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YBL002W

Top 10 functional gene interactors with YBL002W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with HTB2 by heterozygous co-sensitivity:

Query Interactor Correlation
HTB2 HIS3 0.55973
HTB2 SCT1 0.45338
HTB2 RPL19B 0.43957
HTB2 RPL17A 0.4221
HTB2 ADP1 0.40061
HTB2 RPL14A 0.38973
HTB2 RPL34B 0.37193
HTB2 YDR417C 0.36829
HTB2 ACO1 0.36825
HTB2 RPL20B 0.36754

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with HTB2 by homozygous co-sensitivity:

Query Interactor Correlation
HTB2 HST4 0.55506
HTB2 HOS4 0.53473
HTB2 ACS1 0.53297
HTB2 DUG1 0.52079
HTB2 YDL218W 0.51098
HTB2 SPO1 0.50795
HTB2 YDR185C 0.50122
HTB2 SPO23 0.49354
HTB2 YLR050C 0.48725
HTB2 TMA16 0.48038

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YBL002W

Other databases:

Visit YBL002W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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