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Yeast Fitness
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YAR050W / FLO1



Section 1: Phenotypes.
Gene-drug relationships for YAR050W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAR050W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for FLO1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
lapachol 500 uM 5.06383 3.3885e-06
bufexamac 1000 uM 4.82856 7.4914e-06
itraconazole 4.4 uM 4.29671 4.3225e-05
itraconazole 17.7 uM 4.2602 4.863e-05
bufexamac 1000 uM 4.14722 6.9865e-05
latrunculin 6.25 uM 3.73424 0.00090344
flunarizine hydrochloride 93.8 uM 3.65124 0.00032717
caspofungin 10 nM 3.51966 0.00048569
itraconazole 17.7 uM 3.44458 0.00060667
caspofungin 10 nM 3.4087 0.00067416

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for FLO1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cuso4 12000 uM 6.99938 9.8471e-08
synthetic complete for BY4743 0 5.42139 0.00014622
nystatin 10 uM 3.68004 0.0021231
tryptophan dropout 0 3.36791 0.0035732
sorbitol 1.5e+06 uM 3.19738 0.004767
nystatin 10 uM 3.12754 0.0053676
ph8 0 3.10863 0.0055433
nacl 1000 uM 2.94541 0.0073247
lysine dropout 0 2.751 0.0068196
sorbitol 1.5e+06 uM 2.62865 0.0070998

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAR050W

Top 10 functional gene interactors with YAR050W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with FLO1 by heterozygous co-sensitivity:

Query Interactor Correlation
FLO1 YCR061W_p 0.65546
FLO1 YNL092W 0.62412
FLO1 YJR024C 0.61251
FLO1 PFK27 0.59935
FLO1 YDR029W 0.59748
FLO1 DAP2 0.59683
FLO1 YJL007C 0.59638
FLO1 YOL114C 0.59215
FLO1 HIS2 0.58384
FLO1 HOT1 0.58193

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with FLO1 by homozygous co-sensitivity:

Query Interactor Correlation
FLO1 FRE6 0.64025
FLO1 COS1 0.58739
FLO1 PRM9 0.56568
FLO1 FUN26 0.5649
FLO1 YLR118C 0.55275
FLO1 YFL054C 0.52089
FLO1 YPR174C 0.52077
FLO1 SNO1 0.51755
FLO1 LYS21 0.51715
FLO1 MEI5 0.51478

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YAR050W

Other databases:

Visit YAR050W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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