Retrieving results for YAR015W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YAR015W / ADE1



Section 1: Phenotypes.
Gene-drug relationships for YAR015W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAR015W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ADE1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
licl 150 mM 6.92195 3.8756e-08
fk506 0.1 ug/ml 6.36436 1.8979e-07
no drug minimal media 0 5.94039 0.0009652
fk506 0.1 ug/ml 5.54014 2.0627e-06
methotrexate 125 uM 5.09273 7.5875e-06
no drug minimal media 0 4.90703 0.0013459
methotrexate 500 uM 4.21411 9.5608e-05
p-aminobenzoic acid 500 uM 4.1574 0.0001123
parkinsons peptide 250 uM 4.14482 0.00011638
parkinsons peptide 250 uM 4.11378 0.00012706

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ADE1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 6.19652 0.0017245
synthetic complete for BY4743 0 6.18693 0.0017343
potassium disulfite 2500 uM 4.80163 7.1444e-05
synthetic complete for BY4743 0 2.99549 0.028938
licl 100 mM 2.95806 0.0042092
rapamycin 9 nM 2.86416 0.051673
ph4 7.5 2.79652 0.0059626
synthetic complete for BY4743 0 2.70712 0.015163
synthetic complete for BY4743 0 2.65523 0.016346
synthetic complete for BY4743 0 2.63446 0.016847

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAR015W

Top 10 functional gene interactors with YAR015W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ADE1 by heterozygous co-sensitivity:

Query Interactor Correlation
ADE1 YPT7 0.86316
ADE1 ATS1 0.83238
ADE1 YML6 0.82824
ADE1 SEL1 0.81204
ADE1 MRPL39 0.78041
ADE1 TRM9 0.76431
ADE1 YIL067C 0.76095
ADE1 PSP2 0.75062
ADE1 OST6 0.74432
ADE1 SPO7 0.73902

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
 
Homozygous co-fitness interactions

Top 10 interactors with ADE1 by homozygous co-sensitivity:

Query Interactor Correlation
ADE1 YNL296W 0.56373
ADE1 GLE2 0.55194
ADE1 IRC19 0.54817
ADE1 MRP1 0.53931
ADE1 RML2 0.53152
ADE1 MRP21 0.52898
ADE1 NAM2 0.51475
ADE1 MSC1 0.50993
ADE1 SLX8 0.50473
ADE1 SNF2 0.50438

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YAR015W

Other databases:

Visit YAR015W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.