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Yeast Fitness

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YAR008W / SEN34

Section 1: Phenotypes.
Gene-drug relationships for YAR008W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAR008W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for SEN34 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
bithionol 75 uM 16.3709 < 1e-12
bithionol 75 uM 16.3356 < 1e-12
bithionol 75 uM 15.1042 < 1e-12
thiram 15.6 uM 9.25502 3.4571e-12
20 degrees C 0 7.10269 2.8574e-09
lapachol 1000 uM 6.12389 8.7376e-08
latrunculin 3.91 uM 5.65577 1.4735e-06
flufenamic acid 62.5 uM 4.69233 1.1805e-05
hydroxyurea 25000 uM 4.2486 5.0482e-05
miconazole 100 uM 4.17476 6.3981e-05

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YAR008W

Top 10 functional gene interactors with YAR008W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with SEN34 by heterozygous co-sensitivity:

Query Interactor Correlation
SEN34 BUD14 0.76855
SEN34 CDC15 0.72234
SEN34 GAL83 0.68793
SEN34 MRPL49 0.68167
SEN34 SEC59 0.67756
SEN34 YML6 0.67385
SEN34 MDM10 0.67039
SEN34 MRD1 0.66933
SEN34 TAF4 0.66843
SEN34 SPT10 0.66404

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YAR008W

Other databases:

Visit YAR008W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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