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Yeast Fitness
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YAL060W / BDH1



Section 1: Phenotypes.
Gene-drug relationships for YAL060W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL060W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for BDH1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 500 uM 14.3056 < 1e-12
bithionol 75 uM 11.1943 < 1e-12
progesterone 250 uM 10.9522 < 1e-12
methotrexate 500 uM 6.52127 1.2106e-07
fk506 0.1 ug/ml 5.57785 1.8483e-06
fk506 0.1 ug/ml 5.44491 2.7216e-06
methotrexate 500 uM 4.66059 2.6574e-05
latrunculin 6.25 uM 4.03727 0.00047714
methotrexate 500 uM 3.88972 0.00023847
itraconazole 35.4 uM 3.71542 0.00026918

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for BDH1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 11.7171 3.7012e-10
nocodazole 10 ug/ml 8.94132 2.4271e-08
mms 0.002 % 6.25243 0.012319
licl 150 mM 4.48719 3.929e-05
mncl2 2 mM 4.43361 4.5987e-05
cantharidin analog 250 ug/ml 4.34315 5.9936e-05
mechlorethamine 62.5 uM 4.25646 0.025505
rapamycin 5 nM 3.38306 0.00090917
synthetic complete for BY4743 0 3.34191 0.010255
parkinsons peptide 250 uM 3.25881 0.0012711

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAL060W

Top 10 functional gene interactors with YAL060W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with BDH1 by heterozygous co-sensitivity:

Query Interactor Correlation
BDH1 OAF1 0.74584
BDH1 SNC1 0.74494
BDH1 YAR037W_d 0.72174
BDH1 YAT1 0.71603
BDH1 STB4 0.6883
BDH1 YAR030C 0.6877
BDH1 YML002W 0.68749
BDH1 PAU8 0.68556
BDH1 PLB2 0.68205
BDH1 FUN26 0.68143

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with BDH1 by homozygous co-sensitivity:

Query Interactor Correlation
BDH1 YEH1 0.78307
BDH1 YAR037W_d 0.76014
BDH1 YNL303W 0.75796
BDH1 YAL045C 0.75596
BDH1 YER067C-A 0.75373
BDH1 YAR030C 0.74747
BDH1 YOR111W 0.73176
BDH1 HIS3 0.73116
BDH1 YOR114W 0.73079
BDH1 TMA10 0.71922

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YAL060W

Other databases:

Visit YAL060W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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