Retrieving results for YAL054C, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YAL054C / ACS1



Section 1: Phenotypes.
Gene-drug relationships for YAL054C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL054C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for ACS1 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
ketoconazole 11.8 uM 9.44423 3.0249e-08
itraconazole 17.7 uM 7.19703 2.0568e-09
tunicamycin 0.15 uM 5.96236 9.9448e-06
thiabendazole 250 uM 5.39345 1.0995e-06
quinacrine hydrochloride 1000 uM 4.23938 5.2002e-05
itraconazole 17.7 uM 4.2342 5.2876e-05
miconazole 100 uM 3.80807 0.00020259
fluconazole 65.3 uM 3.5847 0.00039985
clotrimazole 1 uM 3.43723 0.00061994
chemdiv 275 62 uM 3.19193 0.0015813

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for ACS1 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
23 degrees C 0 11.7792 1.7391e-07
latrunculin 3 uM 9.3056 1.3357e-08
5-fluorouracil 38.46 uM 7.80938 7.2676e-06
licl 150 mM 7.16697 1.3739e-08
methotrexate 250 uM 6.34917 5.0323e-07
licl 150 mM 5.17287 5.1243e-06
methotrexate 250 uM 3.85385 0.00034182
mitomycin c 1000 uM 3.63827 0.00094005
mitomycin c 1000 uM 3.5869 0.0010539
mncl2 1 mM 3.21258 0.0014381

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAL054C

Top 10 functional gene interactors with YAL054C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with ACS1 by heterozygous co-sensitivity:

Query Interactor Correlation
ACS1 YLR460C 0.47768
ACS1 YPR015C 0.4413
ACS1 YNR066C 0.42281
ACS1 FRE7 0.41131
ACS1 ERV2 0.40269
ACS1 FRM2 0.39371
ACS1 YPR063C 0.3935
ACS1 YOR022C 0.38904
ACS1 REC107 0.3873
ACS1 MNS1 0.37279

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with ACS1 by homozygous co-sensitivity:

Query Interactor Correlation
ACS1 GAS4 0.58803
ACS1 ATG8 0.54868
ACS1 YMR210W 0.54299
ACS1 MUM3 0.54285
ACS1 YMR178W 0.53495
ACS1 HTB2 0.53297
ACS1 YOR052C 0.52698
ACS1 PMA2 0.52349
ACS1 YHR033W 0.52335
ACS1 DUG1 0.52028

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YAL054C

Other databases:

Visit YAL054C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.