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YAL038W / CDC19



Section 1: Phenotypes.
Gene-drug relationships for YAL038W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL038W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CDC19 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 500 uM 14.8734 < 1e-12
5-fluorouracil 76.8 uM 6.0193 5.1324e-07
lapachol 1000 uM 5.8082 2.6228e-07
itraconazole 4.4 uM 5.69765 3.8486e-07
methotrexate 125 uM 5.14231 6.5683e-06
fk506 0.1 ug/ml 4.23238 9.0766e-05
methotrexate 125 uM 3.93954 0.00020748
5-fluorouracil 38.4 uM 3.71105 0.00039138
fk506 0.1 ug/ml 3.63836 0.00047786
fk506 0.05 ug/ml 3.61811 0.00050508

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YAL038W

Top 10 functional gene interactors with YAL038W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CDC19 by heterozygous co-sensitivity:

Query Interactor Correlation
CDC19 YML6 0.84987
CDC19 SEL1 0.80345
CDC19 SPT5 0.80009
CDC19 YML012C-A 0.79839
CDC19 HEM14 0.79486
CDC19 RAD52 0.78948
CDC19 TRM9 0.78328
CDC19 RFA1 0.78271
CDC19 OST1 0.77629
CDC19 SPT10 0.77507

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YAL038W

Other databases:

Visit YAL038W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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