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YAL038W / CDC19

Section 1: Phenotypes.
Gene-drug relationships for YAL038W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL038W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CDC19 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mechlorethamine 500 uM 14.8734 < 1e-12
5-fluorouracil 76.8 uM 6.0193 5.1324e-07
lapachol 1000 uM 5.8082 2.6228e-07
itraconazole 4.4 uM 5.69765 3.8486e-07
methotrexate 125 uM 5.14231 6.5683e-06
fk506 0.1 ug/ml 4.23238 9.0766e-05
methotrexate 125 uM 3.93954 0.00020748
5-fluorouracil 38.4 uM 3.71105 0.00039138
fk506 0.1 ug/ml 3.63836 0.00047786
fk506 0.05 ug/ml 3.61811 0.00050508

More... (click to see all Heterozygous data)

Homozygous knockout:

[No Homozygous results.]

Section 2: Co-fitness interactions.
Gene-gene relationships for YAL038W

Top 10 functional gene interactors with YAL038W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.

Heterozygous co-fitness interactions

Top 10 interactors with CDC19 by heterozygous co-sensitivity:

Query Interactor Correlation
CDC19 YML6 0.84987
CDC19 SEL1 0.80345
CDC19 SPT5 0.80009
CDC19 YML012C-A 0.79839
CDC19 HEM14 0.79486
CDC19 RAD52 0.78948
CDC19 TRM9 0.78328
CDC19 RFA1 0.78271
CDC19 OST1 0.77629
CDC19 SPT10 0.77507

More... (click to see all interactions)

Enriched GO terms of interactors

  • None
  • None
Homozygous co-fitness interactions

[No homozygous results.]

External information about YAL038W

Other databases:

Visit YAL038W in [ SGD | TheBioGrid | BioPixie ]

Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.

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