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Yeast Fitness
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YAL029C / MYO4



Section 1: Phenotypes.
Gene-drug relationships for YAL029C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL029C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MYO4 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorocytosine 15.6 uM 3.41809 0.00065584
dna protein kinase inhibitor 0 3.15228 0.0017538
amoxepine 500 uM 2.96557 0.0023677
parthenolide 1000 uM 2.95397 0.0024439
parthenolide 1000 uM 2.93973 0.0025404
clofoctol 1000 uM 2.91193 0.0027394
miconazole 0.2 uM 2.88983 0.0029078
hydroxyurea 25000 uM 2.88157 0.0029731
nitrendipine 500 uM 2.79463 0.0037491
fenpropimorph 8 nM 2.73911 0.0043386

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MYO4 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
mms 0.002 % 9.97323 0.0049523
myriocin 0.2 ug/ml 9.67434 7.4145e-09
l-dopa 12.5 ug/ml 7.23745 1.1198e-08
fk506 0.1 ug/ml 6.9693 2.4444e-08
licl 100 mM 6.86415 1.0087e-06
synthetic complete for BY4743 0 6.19629 0.004234
hygromycin 13.75 uM 5.0822 6.7198e-06
cadmium chloride 7.81 uM 5.00276 8.5184e-06
ph4 8 4.80645 1.5285e-05
nocodazole 10 ug/ml 4.68795 9.1613e-05

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAL029C

Top 10 functional gene interactors with YAL029C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MYO4 by heterozygous co-sensitivity:

Query Interactor Correlation
MYO4 OAF1 0.704
MYO4 GDH3 0.63452
MYO4 BDH1 0.60876
MYO4 FUN26 0.60028
MYO4 YML030W 0.59035
MYO4 YML003W 0.58114
MYO4 YMR034C 0.57431
MYO4 SNC1 0.57334
MYO4 PAU8 0.56694
MYO4 SUB1 0.56432

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MYO4 by homozygous co-sensitivity:

Query Interactor Correlation
MYO4 FMS1 0.64976
MYO4 YNR066C 0.63637
MYO4 FLC1 0.63524
MYO4 AHT1 0.62628
MYO4 YHR126C 0.62102
MYO4 MUP3 0.61529
MYO4 RNP1 0.61034
MYO4 MLH2 0.60417
MYO4 SST2 0.59491
MYO4 YER186C 0.58287

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about YAL029C

Other databases:

Visit YAL029C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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