Retrieving results for YAL012W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YAL012W / CYS3



Section 1: Phenotypes.
Gene-drug relationships for YAL012W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL012W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for CYS3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
drofenine hydrochloride 750 uM 8.02863 1.1706e-10
caspofungin 10 nM 6.84346 7.0634e-09
thiabendazole 250 uM 5.65639 4.4397e-07
bufexamac 1000 uM 5.42396 9.9006e-07
aminophenazone 250 uM 5.16202 2.427e-06
bufexamac 1000 uM 5.13635 2.6486e-06
metergoline 250 uM 4.85026 6.9653e-06
wiskostatin 29 uM 4.71543 2.2678e-05
thiabendazole 500 uM 4.1964 5.9697e-05
itraconazole 4.4 uM 4.13524 7.2587e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for CYS3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 24.8353 9.8721e-07
synthetic complete for BY4743 0 23.1124 1.4105e-06
synthetic complete for BY4743 0 17.9395 2.0654e-07
synthetic complete for BY4743 0 17.125 2.8408e-07
synthetic complete for BY4743 0 12.9328 1.9208e-06
synthetic complete for BY4743 0 11.1732 5.1257e-06
synthetic complete for BY4743 0 10.8344 5.8131e-05
licl 100 mM 10.208 3.2497e-09
synthetic complete for BY4743 0 9.90026 8.9681e-05
synthetic complete for BY4743 0 9.26503 0.0013304

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAL012W

Top 10 functional gene interactors with YAL012W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with CYS3 by heterozygous co-sensitivity:

Query Interactor Correlation
CYS3 JJJ2 0.37915
CYS3 YGL214W 0.35616
CYS3 YMD8 0.35165
CYS3 YIM1 0.32385
CYS3 TMA7 0.32338
CYS3 YLR281C 0.32296
CYS3 YNL013C 0.32083
CYS3 YPL257W 0.3201
CYS3 RAD5 0.31633
CYS3 RDH54 0.31263

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with CYS3 by homozygous co-sensitivity:

Query Interactor Correlation
CYS3 CKB1 0.34396
CYS3 CAF17 0.33838
CYS3 SNF2 0.31205
CYS3 RPN4 0.30849
CYS3 YPK1 0.30681
CYS3 SMI1 0.29885
CYS3 MEH1 0.29466
CYS3 NBP2 0.29069
CYS3 YGR064W 0.28703
CYS3 YKR074W 0.28664

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:
  • None




External information about YAL012W

Other databases:

Visit YAL012W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.