Retrieving results for YAL002W, please wait...

Yeast Fitness
Database

Quick Search

Enter orf / gene / drug:

(e.g. pex22 or lovastatin)  
Advanced search

YAL002W / VPS8



Section 1: Phenotypes.
Gene-drug relationships for YAL002W
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL002W deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for VPS8 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
cantharidin 250 uM 22.4595 0.00098828
alverine citrate 500 uM 15.8662 0.0019745
alverine citrate 500 uM 13.4509 0.0027408
drofenine hydrochloride 750 uM 8.06264 1.0434e-10
clozapine 500 uM 7.44037 8.8289e-10
fendiline hydrochloride 125 uM 7.09866 2.8978e-09
wiskostatin 29 uM 6.97556 3.3315e-08
telomerase inhibitor ix (Biomol) 500 uM 6.90446 4.0719e-08
benfluorex hydrochloride 250 uM 6.86924 4.4983e-08
cantharidin 250 uM 6.75929 6.1433e-08

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for VPS8 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 42.5599 0.00027581
synthetic complete for BY4743 0 29.1277 4.4431e-05
latrunculin 0.78 uM 28.8895 0.00059801
latrunculin 0.78 uM 27.904 0.00064092
bleomycin 1.13 ug/ml 23.8555 < 1e-12
bleomycin 1.13 ug/ml 23.5263 < 1e-12
latrunculin 0.78 uM 20.5115 0.00012669
synthetic complete for BY4743 0 20.4405 0.0011924
bleomycin 1.7 ug/ml 19.0991 < 1e-12
latrunculin 3 uM 18.0269 < 1e-12

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for YAL002W

Top 10 functional gene interactors with YAL002W. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with VPS8 by heterozygous co-sensitivity:

Query Interactor Correlation
VPS8 VID27 0.40606
VPS8 COG3 0.3623
VPS8 RNA14 0.34804
VPS8 FEN1 0.3129
VPS8 SLI15 0.303
VPS8 RPC82 0.30186
VPS8 RPS17A 0.29525
VPS8 TIF34 0.29352
VPS8 DNF3 0.29335
VPS8 LSM2 0.29269

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with VPS8 by homozygous co-sensitivity:

Query Interactor Correlation
VPS8 VPS9 0.72912
VPS8 VPS27 0.71629
VPS8 VPS24 0.71317
VPS8 VPS21 0.70142
VPS8 VPS4 0.6943
VPS8 SRN2 0.65216
VPS8 VPS38 0.65063
VPS8 BRO1 0.65043
VPS8 DID4 0.63673
VPS8 VPS30 0.61602

More... (click to see all interactions)

Enriched GO terms of interactors

Process:Function:
  • None
Component:




External information about YAL002W

Other databases:

Visit YAL002W in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


Download a plain text version of this page.