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Yeast Fitness
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YAL001C / TFC3



Section 1: Phenotypes.
Gene-drug relationships for YAL001C
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the YAL001C deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for TFC3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
5-fluorouridine 47.5 uM 6.48049 2.5133e-08
tryptanthrin 250 uM 6.00688 5.3201e-07
itraconazole 4.4 uM 5.05266 3.5192e-06
atorvastatin 125 uM 4.9349 5.24e-06
fk506 0.1 ug/ml 4.90318 1.3162e-05
miconazole 100 uM 4.81992 7.7112e-06
mycophenolic acid 500 uM 4.70434 1.1343e-05
nacl 500 mM 4.67398 2.5565e-05
5-fluorouridine 95 uM 4.55462 1.8623e-05
caspofungin 10 nM 4.50992 2.1574e-05

More... (click to see all Heterozygous data)

 
Homozygous knockout:

[No Homozygous results.]




Section 2: Co-fitness interactions.
Gene-gene relationships for YAL001C

Top 10 functional gene interactors with YAL001C. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with TFC3 by heterozygous co-sensitivity:

Query Interactor Correlation
TFC3 BUD14 0.53967
TFC3 ERG5 0.5353
TFC3 SEN34 0.52145
TFC3 CCS1 0.50783
TFC3 YMR018W 0.50686
TFC3 FLC2 0.50669
TFC3 SEL1 0.50188
TFC3 PRP45 0.50039
TFC3 GLO1 0.49863
TFC3 GSF2 0.49794

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None
 
Homozygous co-fitness interactions

[No homozygous results.]




External information about YAL001C

Other databases:

Visit YAL001C in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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