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Yeast Fitness
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YPR138C / MEP3



Section 1: Phenotypes.
Gene-drug relationships for MEP3
(Hillenmeyer et al., Science 2008)

The top 10 experiments that caused a fitness defect in the MEP3 deletion mutants. On the left is a table listing the top 10 conditions inducing sensitivity; on the right is a visualization of those conditions. Edges may appear more than once if the condition was tested multiple times.

We generally recommend using a significance cutoff of p-value < 0.01. For the "phenotype for all genes" analysis, we used p-value < 1e-5 to control for multiple hypothesis testing. For details, see
The Chemical Genomic Portrait of Yeast.

.
Heterozygous knockout:

Top 10 sensitivity-inducing conditions for MEP3 Heterozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
dihydromotuporamine C 15 uM 7.64406 5.1797e-09
methotrexate 500 uM 7.29112 1.3755e-08
dna protein kinase inhibitor 0 6.75425 6.2319e-08
methotrexate 500 uM 6.49395 1.309e-07
wiskostatin 29 uM 6.183 3.1986e-07
tryptanthrin 250 uM 5.84582 8.4843e-07
methotrexate 500 uM 4.02687 0.00016237
methotrexate 125 uM 3.93087 0.00021257
norcantharidin 2500 uM 3.70566 0.00039723
allyl disulfide 0.06 % 3.70233 0.00040089

More... (click to see all Heterozygous data)

 
Homozygous knockout:

Top 10 sensitivity-inducing conditions for MEP3 Homozygous deletion:

Condition1 Conc Unit z_result_nm z_tdist_pval_nm
synthetic complete for BY4743 0 11.6012 0.0036741
synthetic complete for BY4743 0 8.15371 0.0073552
synthetic complete for BY4743 0 6.30777 0.0040258
wiskostatin 29 uM 5.93042 5.3016e-07
tryptanthrin 250 uM 4.32172 6.3808e-05
synthetic complete for BY4743 0 4.11027 0.013039
sorbitol 1.5e+06 uM 3.88933 0.00058933
allyl disulfide 0.06 % 3.80022 0.00028591
synthetic complete for BY4743 400 uM 3.73805 0.00081842
sorbitol 1.5e+06 uM 3.68675 0.0005262

More... (click to see all Homozygous data)





Section 2: Co-fitness interactions.
Gene-gene relationships for MEP3

Top 10 functional gene interactors with MEP3. These relationships were calculated using the Pearson correlation of each gene's scores across drug experiments.



Heterozygous co-fitness interactions

Top 10 interactors with MEP3 by heterozygous co-sensitivity:

Query Interactor Correlation
MEP3 IZH1 0.53892
MEP3 YMR102C 0.51776
MEP3 YOR263C 0.51048
MEP3 YAL027W 0.50973
MEP3 SVS1 0.48607
MEP3 REX4 0.486
MEP3 ALG5 0.48028
MEP3 PPR1 0.47872
MEP3 GMH1 0.47536
MEP3 YOR214C 0.47263

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:Component:
  • None
 
Homozygous co-fitness interactions

Top 10 interactors with MEP3 by homozygous co-sensitivity:

Query Interactor Correlation
MEP3 SSU1 0.56945
MEP3 NCA2 0.56012
MEP3 YLR296W 0.55987
MEP3 YLR112W 0.5518
MEP3 MNT4 0.54488
MEP3 PIG1 0.54161
MEP3 YLR400W 0.53519
MEP3 TMA17 0.51945
MEP3 SPR28 0.51523
MEP3 YOR263C 0.51485

More... (click to see all interactions)

Enriched GO terms of interactors

Process:
  • None
Function:
  • None
Component:
  • None




External information about MEP3

Other databases:

Visit MEP3 in [ SGD | TheBioGrid | BioPixie ]


Previously known GO terms:
Visualizations of other datasets

Co-expression, physical interaction, synthetic lethality. Can post if requested by users.


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